News

In December 2020, Infrafrontier launched an attractive free-of-charge service for the biomedical research community fighting against the COVID-19 pandemic. The Infrafrontier call turned out to be the most successful open call of the consortium so far. 21 scientific institutions from eight countries applied to be one of the five research projects that an INFRAFRONTIER expert… Read more

On 5-16 July 2021, the third course on Mouse Embryology, Anatomy, Histology, and Anatomical Basis of Imaging will take place on-line. The aim is to provide students with basic and expert knowledge to phenotype morphologically mouse models of human diseases. At this course, expert mouse embryologists, anatomists, pathologists and researchers from Europe and the US… Read more

5 – 16 July, 2021 (On-Line Summer Course) The third course on Mouse Embryology, Anatomy, Histology, and Anatomical Basis of Imaging will take place on-line. The aim is to provide graduate, master, PhD and postdoc students with basic and expert knowledge to phenotype morphologically mouse models of human diseases. At this course, expert mouse embryologists,… Read more

In four Thursday Zoom sessions on June 3, 10, 17 and 24, the Leiden University Medical Center, the Netherlands Cancer Institute, the Amsterdam University Medical Centers and the University of Amsterdam organize the 11th edition of the workshop on Innovative Mouse Models (IMM2021). Due to the Covid-19 pandemic the workshop will be held on-line. Registration… Read more

The 75th ESFRI Forum Plenary was held virtually on 23rd – 24th March 2021. The first Open Session organised as a part of the ESFRI meeting brought together the ESFRI Delegates and representatives of the ESFRI Research Infrastructures to discuss the response to the COVID-19 pandemic. The main focus was put on the activities of… Read more

Neutralizing antibodies targeting the receptor binding domain (RBD) of the SARS-CoV-2 Spike (S) are among the most promising approaches against coronavirus disease 2019 (COVID-19)1,2. We developed a bispecific, IgG1-like molecule (CoV-X2) based on two antibodies derived from COVID-19 convalescent donors, C121 and C1353. CoV-X2 simultaneously binds two independent sites on the RBD and, unlike its… Read more

The CCP primary goal is to perform excellent research. In the period 2021 – 2030, together with other foreign centers gathered in the International Mouse Phenotyping Consortium we plan  to deliver jointly broad-based genomic insights into the function of human genetic variation in both coding and non-coding sequences that underpin future developments in precision medicine,… Read more

Dancing house blue. It shone in honor of all the “angelic families” who face a difficult fate every day. On 15th February, we celebrated International Angelman Syndrome Day. More than 100 patients live with this rare genetic disease among us in the Czech Republic. The initiators of the event are the parents of little Oliver… Read more

Woo, X.Y., Giordano, J., Srivastava, A. et al. Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts. Nat Genet 53, 86–99 (2021). https://doi.org/10.1038/s41588-020-00750-6 Patient-derived xenografts (PDXs) are resected human tumors engrafted into mice for preclinical studies and therapeutic testing. It has been proposed that the mouse host affects tumor evolution during PDX engraftment and propagation, affecting… Read more

Do not miss the best of IMPC work, including research publications, data updates, global collaborations in 2020, and IMPC plans for the future. https://review.mousephenotype.org/ Read more