We are enhancing our
understanding
of the genetic basis for
human diseases

What can we help you with

Microinjection

Model Generation

Genetically modified rodent models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. 
Phenotyping

Phenotyping

The genomes of humans, mice and other species have been completely sequenced, yet the knowledge of genome sequences as such does not shed light on questions concerning the functions of these sequences. 

Animal Facility

The Animal Facility Module of the Czech Center for Phenogenomics is based on the latest advances in housing, breeding and care of laboratory mice and rats. 
Mouse tumors

Preclinical Testing

The Czech Centre for Phenogenomics can offer a very broad portfolio of highly standardized assays useful for preclinical studies on rodents including established disease models. 

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Latest News

18. 11. 2022

ISIDORe new calls for transnational access open

We would like to inform you about a new range of transnational access calls recently launched under the ISIDORe project. These are free-of-charge open calls on specific pathogens and related-services accessible to researchers in the EU and abroad. Details about the open calls are available at ISIDORe website. Find out more about how INFRAFRONTIER contributes…

10. 10. 2022

Join INFRAFRONTIER-IMPC Satellite Event at ICRI 2022

Global and European Infrastructures IMPC and INFRAFRONTIER Towards the Deciphering of Gene Functions for Human Health 18 October 2022, 13:00 – 15:00  Hybrid event (Brno, Czech Republic + Zoom) European and world-wide research infrastructures such as IMPC and INFRAFRONTIER will provide comprehensive resources to unravel gene function in physiology and disease. These infrastructures are used…

03. 10. 2022

CCP user Svante Pääbo awarded The Nobel Prize in Physiology or Medicine 2022

The Nobel Prize in Physiology or Medicine 2022 was awarded to Svante Pääbo “for his discoveries concerning the genomes of extinct hominins and human evolution”. More information here. Svante Pääbo from Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, uses research services of the Czech Centre for Phenogenomics, and was a keynote speaker at…

About Czech Centre for Phenogenomics

Genetically modified mouse models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. Crucial for this technology is the ability to control the expression of genes of interest. It is possible to increase or decrease gene expression, or eliminate the expression of a gene completely.

Transgenic and gene knockout/knockin technologies have become important experimental tools for assigning functions to genes at the level of whole complexity of organism, creating models of genetic disorders, evaluating effects drugs and toxins, thus helping to answer fundamental issues in basic and applied research.