We are enhancing our
understanding
of the genetic basis for
human diseases

What can we help you with

Microinjection

Model Generation

Genetically modified rodent models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. 
Phenotyping

Phenotyping

The genomes of humans, mice and other species have been completely sequenced, yet the knowledge of genome sequences as such does not shed light on questions concerning the functions of these sequences. 

Animal Facility

The Animal Facility Module of the Czech Center for Phenogenomics is based on the latest advances in housing, breeding and care of laboratory mice and rats. 
Mouse tumors

Preclinical Testing

The Czech Centre for Phenogenomics can offer a very broad portfolio of highly standardized assays useful for preclinical studies on rodents including established disease models. 

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Latest News

19. 01. 2021

Infrafrontier trans-national access call: COVID-19 therapeutics pipeline

Application deadline: 31 January 2021 Application costs: This TA Call is free-of-charge for the selected applicants. Main objective of this INFRAFRONTIER2020 Trans-national Access Call is to provide extensive user support to the selected projects for assessing novel potential vaccine and treatment compounds for COVID-19. As starting material for the TA service, only sufficient amounts of the…

15. 01. 2021

Cost-effective generation of mice based on Cre/loxP-system by zygote electroporation of Cre protein

Transgenic Unit of the Czech Centre for Phenogenomics has grown in recent years to offer expanded gene and genome engineering services to researchers by applying the latest cutting-edge technologies such as TALENs, CRISPR/Cas9(Cas12a)-based tools, Easi-CRISPR and others. The introduction of specific mutations by electroporation of zygotes is preferentially used over conventional pronuclear injections and other…

12. 01. 2021

Radislav Sedlacek became the chairman of IMPC

Nineteen research institutions from around the world, including the Czech Republic, joined forces within the IMPC (International Mouse Phenotyping Consortium) to jointly decipher the function of all, approximately 20,000 mammalian (and human), genes. The result is an ever-growing “encyclopaedia” that helps to identify the emergence of human diseases and propose new treatments. Thanks to his…

About Czech Centre for Phenogenomics

Genetically modified mouse models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. Crucial for this technology is the ability to control the expression of genes of interest. It is possible to increase or decrease gene expression, or eliminate the expression of a gene completely.

Transgenic and gene knockout/knockin technologies have become important experimental tools for assigning functions to genes at the level of whole complexity of organism, creating models of genetic disorders, evaluating effects drugs and toxins, thus helping to answer fundamental issues in basic and applied research.