We are enhancing our
understanding
of the genetic basis for
human diseases

What can we help you with

Microinjection

Model Generation

Genetically modified rodent models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. 
Phenotyping

Phenotyping

The genomes of humans, mice and other species have been completely sequenced, yet the knowledge of genome sequences as such does not shed light on questions concerning the functions of these sequences. 

Animal Facility

The Animal Facility Module of the Czech Center for Phenogenomics is based on the latest advances in housing, breeding and care of laboratory mice and rats. 
Mouse tumors

Preclinical Testing

The Czech Centre for Phenogenomics can offer a very broad portfolio of highly standardized assays useful for preclinical studies on rodents including established disease models. 

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Latest News

01. 10. 2024

Open Call for Proposals: Nominate Your Gene or Disease

Open Call for Proposals: Nominate Your Gene or Disease The RD-Factory Program invites proposals for preclinical studies aimed at rare human genetic diseases. This open call seeks contributions from the scientific community, rare disease experts, societies, and patient families to: More information – Rare Disease Factory

26. 08. 2024

Last day for abstract submission at the 6th CCP Phenogenomics Conference 2024

Is your research topic related to rare diseases? Do you want to get more information on how experimental models can boost your research? Join us for the 6th CCP Phenogenomics Conference. Deadline for abstract submission is 27th August 2024, so do not miss the opportunity to share research outcomes with our community. Register at: https://www.ccp-conference.cz/registration-abstracts-submission/

01. 08. 2024

Interested in rare diseases? Register for the 6th CCP Phenogenomics Conference 2024

Are you an expert in rare diseases or does someone close to you suffer from a rare disease?Register to our 6th CCP Phenogenomic Conference 2024, where we will present examples of good practice in collaboration between rare disease researchers and patient organisations in Session 7 “Rare diseases & bottom-up efforts to develop (gene) therapies” Registration…

About Czech Centre for Phenogenomics

Genetically modified mouse models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. Crucial for this technology is the ability to control the expression of genes of interest. It is possible to increase or decrease gene expression, or eliminate the expression of a gene completely.

Transgenic and gene knockout/knockin technologies have become important experimental tools for assigning functions to genes at the level of whole complexity of organism, creating models of genetic disorders, evaluating effects drugs and toxins, thus helping to answer fundamental issues in basic and applied research.