We are enhancing our
understanding
of the genetic basis for
human diseases

What can we help you with

Microinjection

Model Generation

Genetically modified rodent models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. 
Phenotyping

Phenotyping

The genomes of humans, mice and other species have been completely sequenced, yet the knowledge of genome sequences as such does not shed light on questions concerning the functions of these sequences. 

Animal Facility

The Animal Facility Module of the Czech Center for Phenogenomics is based on the latest advances in housing, breeding and care of laboratory mice and rats. 
Mouse tumors

Preclinical Testing

The Czech Centre for Phenogenomics can offer a very broad portfolio of highly standardized assays useful for preclinical studies on rodents including established disease models. 

From our Twitter

Latest News

26. 02. 2021

CCP celebrates the Rare Disease Day 2021

The CCP primary goal is to perform excellent research. In the period 2021 – 2030, together with other foreign centres gathered in the International Mouse Phenotyping Consortium we plan  to deliver jointly broad-based genomic insights into the function of human genetic variation in both coding and non-coding sequences that underpin future developments in precision medicine,…

17. 02. 2021

We lit the Dancing House blue, hoping for a cure for little Oliver and the other “angel children”, on 15th February

Dancing house blue. It shone in honor of all the “angelic families” who face a difficult fate every day. On 15th February, we celebrated International Angelman Syndrome Day. More than 100 patients live with this rare genetic disease among us in the Czech Republic. The initiators of the event are the parents of little Oliver…

12. 02. 2021

EuroPDX and PDXNet consortia publish a milestone paper on PDX reliability

Woo, X.Y., Giordano, J., Srivastava, A. et al. Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts. Nat Genet 53, 86–99 (2021). https://doi.org/10.1038/s41588-020-00750-6 Patient-derived xenografts (PDXs) are resected human tumors engrafted into mice for preclinical studies and therapeutic testing. It has been proposed that the mouse host affects tumor evolution during PDX engraftment and propagation, affecting…

About Czech Centre for Phenogenomics

Genetically modified mouse models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. Crucial for this technology is the ability to control the expression of genes of interest. It is possible to increase or decrease gene expression, or eliminate the expression of a gene completely.

Transgenic and gene knockout/knockin technologies have become important experimental tools for assigning functions to genes at the level of whole complexity of organism, creating models of genetic disorders, evaluating effects drugs and toxins, thus helping to answer fundamental issues in basic and applied research.