We are enhancing our
understanding
of the genetic basis for
human diseases

What can we help you with

Microinjection

Model Generation

Genetically modified rodent models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. 
Phenotyping

Phenotyping

The genomes of humans, mice and other species have been completely sequenced, yet the knowledge of genome sequences as such does not shed light on questions concerning the functions of these sequences. 

Animal Facility

The Animal Facility Module of the Czech Center for Phenogenomics is based on the latest advances in housing, breeding and care of laboratory mice and rats. 
Mouse tumors

Preclinical Testing

The Czech Centre for Phenogenomics can offer a very broad portfolio of highly standardized assays useful for preclinical studies on rodents including established disease models. 

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Latest News

03. 10. 2022

CCP user Svante Pääbo awarded The Nobel Prize in Physiology or Medicine 2022

The Nobel Prize in Physiology or Medicine 2022 was awarded to Svante Pääbo “for his discoveries concerning the genomes of extinct hominins and human evolution”. More information here. Svante Pääbo from Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, uses research services of the Czech Centre for Phenogenomics, and was a keynote speaker at…

29. 09. 2022

10 PhD fellowships in Gene Therapy of Rare Diseases in EU funded Doctoral Network

GetRADI Doctoral Network is hiring !!! Do not miss the deadline on 31 October 2022. Institute of Molecular Genetics of the Czech Academy of Sciences, Leiden University Medical Center, University of Copenhagen, Medical Center University of Freiburg, AstraZeneca, Max Delbrück Centre for Molecular Medicine, Miltenyi Biotech Prague (CZ), Leiden (NL), Freiburg (DE), Copenhagen (DK), Gothenburg…

01. 09. 2022

1 PhD position in exosome mediated gene therapy of Diamond Blackfan anemia for the MSCA Doctoral Networks project “Gene Therapy of Rare Diseases” (GetRadi)

Institute of Molecular Genetics of the Czech Academy of Sciences invites applications for the following open position: 1 PhD position in exosome mediated gene therapy of Diamond Blackfan anemia for the MSCA Doctoral Networks project “Gene Therapy of Rare Diseases” (GetRadi) STARTING DATE: March 1, 2023 DURATION: 36 Months EU RESEARCH AND INNOVATION PROGRAMME: Horizon…

About Czech Centre for Phenogenomics

Genetically modified mouse models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. Crucial for this technology is the ability to control the expression of genes of interest. It is possible to increase or decrease gene expression, or eliminate the expression of a gene completely.

Transgenic and gene knockout/knockin technologies have become important experimental tools for assigning functions to genes at the level of whole complexity of organism, creating models of genetic disorders, evaluating effects drugs and toxins, thus helping to answer fundamental issues in basic and applied research.