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Isoplexis IsoLight Automated Celluar Proteomic in CCP

08. 08. 2022 Information News PR Service

We would like to inform our users that CCP now offers automated single cell functional proteomics analysis on the Isoplexis platform enabling for single cell functional immunophenotyping or phospho-protein analysis. If you want to know more about the device and services available in CCP for your research please check the details at our immunology unit…

AV21 Centre for Preclinical Testing: The path form the test tube to the patients

15. 07. 2022 Information News PR Service

To test substances that have succeeded in basic research and help them on the long journey from the test tube to the development of new drugs. This is the goal of the Centre for Preclinical Testing, funded by the Strategy of the Czech Academy of Sciences AV21. The centre is run in close collaboration of…

First call to access the ISIDORe resources dedicated to SARS-CoV-2 and COVID-19

10. 06. 2022 Call News Service

The first call is divided into six main sections which are: Surveillance & Epidemic Risk Management; Understanding SARS-CoV-2 & Covid-19; Diagnostics; Therapeutics; Vaccines; and Social Sciences & Epidemiology. The call is multidisciplinary and open to all scientists both from academia and private sector, including the partners of the ISIDORe consortium. The users wishing to benefit…

Preclinical testing of venom-derived compounds – open call for services

02. 05. 2022 Call Service

In the framework of the EUVEN COST Action the unique phenotyping infrastructure Czech Centre for Phenogenomics (CCP) will support researchers in searching for the novel utilization of venom-derived compounds and identifying their translational potential and identifying physiological functions of toxin compounds. CCP offers the following services free of charge within this open call: Acute toxicity…

Covid-19 mouse models available at CCP

02. 09. 2021 News Service

Ace2 knock-out model A number of promising COVID-19 therapies is focused on targeting the Ace2 receptor. Thus, it is desired to evaluate: the potential of Ace2 blocking to prevent viral entry into the cells unwanted off-target effects caused by Ace2 deficiency. Ace2 deficient mutant mice provide an excellent tool for these types of experiments. Tmprss2…

CCP provides services under Infrafrontier COVID-19 Open Call

19. 05. 2021 Call Service

In December 2020, Infrafrontier launched an attractive free-of-charge service for the biomedical research community fighting against the COVID-19 pandemic. The Infrafrontier call turned out to be the most successful open call of the consortium so far. 21 scientific institutions from eight countries applied to be one of the five research projects that an INFRAFRONTIER expert…

EuroPDX and PDXNet consortia publish a milestone paper on PDX reliability

12. 02. 2021 Information News Service

Woo, X.Y., Giordano, J., Srivastava, A. et al. Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts. Nat Genet 53, 86–99 (2021). https://doi.org/10.1038/s41588-020-00750-6 Patient-derived xenografts (PDXs) are resected human tumors engrafted into mice for preclinical studies and therapeutic testing. It has been proposed that the mouse host affects tumor evolution during PDX engraftment and propagation, affecting…

Cost-effective generation of mice based on Cre/loxP-system by zygote electroporation of Cre protein

15. 01. 2021 News Publication Service

Transgenic Unit of the Czech Centre for Phenogenomics has grown in recent years to offer expanded gene and genome engineering services to researchers by applying the latest cutting-edge technologies such as TALENs, CRISPR/Cas9(Cas12a)-based tools, Easi-CRISPR and others. The introduction of specific mutations by electroporation of zygotes is preferentially used over conventional pronuclear injections and other…

Call to support COVID-19 researcher projects by priority access to CCP

06. 05. 2020 Call Service

Czech Centre for Phenogenomics (IMG CAS) offers immediate support to COVID-19 researcher projects by priority access to the national large research infrastructure. CCP generates rodent models related to diagnosis, treatment and prevention of COVID-19 virus infection (e.g. several serine protease mouse mutant lines). Project proposals can be submitted by email to ccp@phenogenomics.cz Proposals will be…

CCP Open Call / Cryo-archiving of mouse models

15. 11. 2019 Call Information PR Service

Main objective of this open call is to facilitate access for the wider biomedical research community to the unique infrastructure. Czech Centre for Phenogenomics will provide cryo-preservation of 15 mouse lines (sperms) preferentially on C57Bl/6 backgrounds free of charge. Additionally, we offer to archive and deposit the mouse line into the EMMA repository. Mouse strains…