General information

With staff over 100 people the CCP is one of the largest national research infrastructures in the field of biomedicine. The centre is located in the municipality of Vestec south of the capital city of Prague in the Czech Republic. Set on the campus of the BIOCEV, CCP is a state of the art facility combining the generation, phenotyping and archiving of rodent strains. As a member of the International Mouse Phenotyping Consortium (IMPC) and INFRAFRONTIER, CCP is dedicated to the goal of systematic genome-wide phenotyping project of knock-out mice in order to provide the broader research community with a lasting resource of mammalian gene function

The CCP is part of the Institute of Molecular Genetics of the Czech Academy of Sciences (IMG), a leading Czech research institute in the field of molecular biology and genetics.

The applications in English including letter of interest & structured CV and (if relevant) a list of publications and letters of reference should be sent to Mr. Libor Daněk via email

What we offer to our employees?

A stimulating and challenging work environment, various opportunities for career advancement, a competitive salary and a wide spectrum of benefits. The positions are available immediately (if not stated otherwise) for an initial fixed-term contract (1 year) with an expected longer-term extension upon demonstrated proficiency.

We thank all who apply for their interest; however, only those candidates who are considered for an interview will be contacted. All vacancies are open until filled or otherwise stated.

All positions have place of work in the BIOCEV campus in Vestec in close vicinity to Prague.

Currently we are seeking candidates to following positions:

MALDI Imaging Researcher

MALDI imaging unit as a part of Metabolomics unit is focused mainly to small molecule metabolite analysis in biological fluids and broad range of tissues. Unit is equipped with state-of-the-art instruments covering LC-MS and MALDI imaging MS instruments.

The main responsibilities include but are not limited to:

  • Tissue sample processing mainly by histological methods (cryosectioning)
  • New protocol and method development (metabolites and peptides)
  • Sample measurement and data pre-processing, post-processing and analysis
  • Involvement in writing grant applications and in publications

The best candidate has a university diploma in analytical chemistry, biochemistry, medical, pharmacy or biology-relevant field. Routine hands-on experience from biological lab is a must as well as ability to communicate in English. Previous experience with LC-MS or MALDI technique, metabolomics or proteomics is considered as advantageous.

Appropriate training and introduction to the field will be given.

Unit Head for Lung Function Phenotyping

The lung function unit is part of standardised phenotyping pipeline, which is involved in IMPC phenotyping effort. The lung function unit focuses on understanding the role of both genetic, environmental and pharmacological factors on lung physiology, homeostasis and mechanics in mouse and rat models. Unit is in close collaboration with other units dedicated for cardiovascular, immunology and histology research and its work is supported by all units within phenotyping module i.e. cardiology, histopathology, bioimaging, electrophysiology, metabolism, PDX and Cancer models etc.

The main responsibilities include but are not limited to:

  • Organisation and supervision of the unit including management of lab technicians or specialists
  • Design and running of experiments including direct ventilation with Scireq devices with standard and advance measurements of lung mechanics parameters, tissue collection and immunological analysis of lung disease models.
  • Data analysis and interpretation
  • Oversee the optimization of current procedures and development and establishment of new techniques, secondary tests and challenges
  • Writing and maintaining SOPs
  • Supervision and consulting of complex projects related to lung and cardiovascular system
  • Involvement in writing grant applications and in publications
  • (Future) possibility to run own research projects

The successful candidate will hold a PhD in a biological discipline with proved experience in lung physiology. Must have experience with handling and working with rodents especially mice and rats. General laboratory experience and knowledge of substance administration is important but not essential. Previous experience with Scireq devices and ultrasound imaging (Vevo system) is considered advantageous as well as experience with pharmacological treatment of lung disease models.