News

Woo, X.Y., Giordano, J., Srivastava, A. et al. Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts. Nat Genet 53, 86–99 (2021). https://doi.org/10.1038/s41588-020-00750-6 Patient-derived xenografts (PDXs) are resected human tumors engrafted into mice for preclinical studies and therapeutic testing. It has been proposed that the mouse host affects tumor evolution during PDX engraftment and propagation, affecting… Read more

Do not miss the best of IMPC work, including research publications, data updates, global collaborations in 2020, and IMPC plans for the future. https://review.mousephenotype.org/ Read more

The aim of the meeting is to introduce top Czech institutions and companies that excel in innovations and technological development to Japanese partners. The meeting will be held in English. The Czech Centre for Phenogenomics will be introduced in the HealthTech section on Tuesday 25th February 2021 (9:30 – 10:30). Innovation days are an ideal… Read more

The IMPC is pleased to announce the election of a new Senior Leadership Team. Radislav Sedláček is the new Chair of the IMPC, and Yann Herault the new Vice-Chair. Steve Brown, who was the Chair of the IMPC, has stepped down to become the Past Chair. Read the full article at the IMPC website. Read more

Czech scientists tested a new antibody against covid-19, which is suitable for prevention and treatment and prevents the virus from mutating. Radislav Sedlacek from CCP and Daniel Ruzicka from the Biology Centre of the Czech Academy of Sciences and the Veterinary Research Institute will answer questions of journalists today (26th January) at 15:00 during a… Read more

Researchers from the Czech Centre for Phenogenomics contributed to the paper “Bispecific antibody prevents SARS-CoV-2 escape and protects mice from disease“ Raoul De Gasparo, Mattia Pedotti, Luca Simonelli, Petr Nickl, Frauke Muecksch, Julio C. C. Lorenzi, Federica Mazzola, Davide Magrì, Tereza Michalcikova, Jan Haviernik, Vaclav Honig, Irene Cassaniti, Elena Percivalle, Blanka Mrazkova, Natalie Polakova, Andrea… Read more

Application deadline: EXTENDED 28 Febuary 2021 Application costs: This TA Call is free-of-charge for the selected applicants. Main objective of this INFRAFRONTIER2020 Trans-national Access Call is to provide extensive user support to the selected projects for assessing novel potential vaccine and treatment compounds for COVID-19. As starting material for the TA service, only sufficient amounts of… Read more

Transgenic Unit of the Czech Centre for Phenogenomics has grown in recent years to offer expanded gene and genome engineering services to researchers by applying the latest cutting-edge technologies such as TALENs, CRISPR/Cas9(Cas12a)-based tools, Easi-CRISPR and others. The introduction of specific mutations by electroporation of zygotes is preferentially used over conventional pronuclear injections and other… Read more

Nineteen research institutions from around the world, including the Czech Republic, joined forces within the IMPC (International Mouse Phenotyping Consortium) to jointly decipher the function of all, approximately 20,000 mammalian (and human), genes. The result is an ever-growing “encyclopaedia” that helps to identify the emergence of human diseases and propose new treatments. Thanks to his… Read more

16 – 17 September 2021 / Vestec, Czech Republic The Conference was divided into two blocks. The first day was devoted to the theme “Human diseases and models“. The second day was specifically dedicated to preclinical development, including covid-19, which focused on translation of the basic research into the application. The Conference provided an excellent… Read more