Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice

25. 03. 2021 News Paper Publication

Neutralizing antibodies targeting the receptor binding domain (RBD) of the SARS-CoV-2 Spike (S) are among the most promising approaches against coronavirus disease 2019 (COVID-19)1,2. We developed a bispecific, IgG1-like molecule (CoV-X2) based on two antibodies derived from COVID-19 convalescent donors, C121 and C1353. CoV-X2 simultaneously binds two independent sites on the RBD and, unlike its…

IMPC 2020 annual highlights

Do not miss the best of IMPC work, including research publications, data updates, global collaborations in 2020, and IMPC plans for the future.

Bispecific antibody prevents SARS-CoV-2 escape and protects mice from disease

25. 01. 2021 News Paper Publication

Researchers from the Czech Centre for Phenogenomics contributed to the paper “Bispecific antibody prevents SARS-CoV-2 escape and protects mice from disease“ Raoul De Gasparo, Mattia Pedotti, Luca Simonelli, Petr Nickl, Frauke Muecksch, Julio C. C. Lorenzi, Federica Mazzola, Davide Magrì, Tereza Michalcikova, Jan Haviernik, Vaclav Honig, Irene Cassaniti, Elena Percivalle, Blanka Mrazkova, Natalie Polakova, Andrea…

Cost-effective generation of mice based on Cre/loxP-system by zygote electroporation of Cre protein

15. 01. 2021 News Publication Service

Transgenic Unit of the Czech Centre for Phenogenomics has grown in recent years to offer expanded gene and genome engineering services to researchers by applying the latest cutting-edge technologies such as TALENs, CRISPR/Cas9(Cas12a)-based tools, Easi-CRISPR and others. The introduction of specific mutations by electroporation of zygotes is preferentially used over conventional pronuclear injections and other…

IMPC is a research infrastructures of global relevance

The International Mouse Phenotyping Consortium Global Research Infrastructures (IMPC GRI) addresses one of the grand challenges for biology and biomedical science in the 21st century – to determine the function of all the genes in the human genome and their role in disease. A recent report by the Group of Senior Officials on Global Research…

First issue of our newsletter

21. 12. 2015 Information Publication

We proudly announce that the first issue of our informational newsletter is available for download in PDF format.

CCP provides new targeting tools for ROSA locus

Dr. Radislav Sedlacek and his team from the Institute of Molecular Genetics has recently published new paper on gene targeting of Rosa26 locus using TALENs. Petr Kasparek, Michaela Krausova, Radka Haneckova, Vitezslav Kriz, Olga Zbodakova,Vladimir Korinek, Radislav Sedlacek. Efficient gene targeting of the Rosa26 locus in mouse zygotes using TALE nucleases. FEBS Letters. Published online: September 18,…

New papers by team of Pavel Stopka

Our colleague Pavel Stopka and his team from the Faculty of Science of Charles University has recently published two papers related to CCP/BIOCEV project. Klinovska K, Sebkova N2, Dvorakova-Hortova K. Sperm-egg fusion: a molecular enigma of Mammalian reproduction. Int J Mol Sci. 2014 Jun 13;15(6):10652-68. doi: 10.3390/ijms150610652. Dvorakova-Hortova K, Sidlova A, Ded L, Hladovcova D,…

Publication in CELL journal

25. 11. 2013 Information Publication

We are supporting research projects with new fast transgenic mouse technology employing TAL effector nucleases – read more in Flemr M, Malik R, Franke V, Nejepinska J, Sedlacek R, Vlahovicek K, Svoboda P: A Retrotransposon-Driven Dicer Isoform Directs Endogenous Small Interfering RNA Production in Mouse Oocytes. Cell 2013; doi:10.1016/j.cell.2013.10.001 / 155 (4) 807-816.

New publication in Oncogene

One of respectable research journals Oncogene, a member of Nature Publishing Group, recently published in its online version the article by Petra Bašová, Vít Pospíšil and co-authors from Dr. Tomáš Stopka’s research group at the Pathophysiology department, First Medical Faculty, Charles University in Prague. This research group is one of new incoming teams in the…