Paper

Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice

25. 03. 2021 News Paper Publication

Neutralizing antibodies targeting the receptor binding domain (RBD) of the SARS-CoV-2 Spike (S) are among the most promising approaches against coronavirus disease 2019 (COVID-19)1,2. We developed a bispecific, IgG1-like molecule (CoV-X2) based on two antibodies derived from COVID-19 convalescent donors, C121 and C1353. CoV-X2 simultaneously binds two independent sites on the RBD and, unlike its…

Bispecific antibody prevents SARS-CoV-2 escape and protects mice from disease

25. 01. 2021 News Paper Publication

Researchers from the Czech Centre for Phenogenomics contributed to the paper “Bispecific antibody prevents SARS-CoV-2 escape and protects mice from disease“ Raoul De Gasparo, Mattia Pedotti, Luca Simonelli, Petr Nickl, Frauke Muecksch, Julio C. C. Lorenzi, Federica Mazzola, Davide Magrì, Tereza Michalcikova, Jan Haviernik, Vaclav Honig, Irene Cassaniti, Elena Percivalle, Blanka Mrazkova, Natalie Polakova, Andrea…

IMPC is a research infrastructures of global relevance

The International Mouse Phenotyping Consortium Global Research Infrastructures (IMPC GRI) addresses one of the grand challenges for biology and biomedical science in the 21st century – to determine the function of all the genes in the human genome and their role in disease. A recent report by the Group of Senior Officials on Global Research…

CCP provides new targeting tools for ROSA locus

Dr. Radislav Sedlacek and his team from the Institute of Molecular Genetics has recently published new paper on gene targeting of Rosa26 locus using TALENs. Petr Kasparek, Michaela Krausova, Radka Haneckova, Vitezslav Kriz, Olga Zbodakova,Vladimir Korinek, Radislav Sedlacek. Efficient gene targeting of the Rosa26 locus in mouse zygotes using TALE nucleases. FEBS Letters. Published online: September 18,…

New papers by team of Pavel Stopka

Our colleague Pavel Stopka and his team from the Faculty of Science of Charles University has recently published two papers related to CCP/BIOCEV project. Klinovska K, Sebkova N2, Dvorakova-Hortova K. Sperm-egg fusion: a molecular enigma of Mammalian reproduction. Int J Mol Sci. 2014 Jun 13;15(6):10652-68. doi: 10.3390/ijms150610652. Dvorakova-Hortova K, Sidlova A, Ded L, Hladovcova D,…