Mouse models from the Czech Centre for Phenogenomics help in researching Angelman’s syndrome

We are celebrating the International Angelman Day on 15th February.

Angelman’s syndrome is an inherited disease of the central nervous system that causes severe physical and mental disabilities.

The team of the Czech Center for Phenogenomics is engaged in research of Angelman’s syndrome (and other rare diseases) on mouse models created by us or already established. We are currently collecting data on Angelman’s syndrome manifestations in mouse models. For these purposes, we use an extensive phenotyping module of our centre with an emphasis on neurobehavioral tests.

The path from basic research to the implementation of successful treatment is not easy, and this is especially true in gene therapy. It is currently a very costly and technically challenging technology, associated with a number of ethical issues and treatment safety.

Therefore, we are grateful to people who, despite the unpredictable future, believe in and support our research results. Specifically, many thanks go to the Association of Gene Therapy (ASGENT), our long-term supporter, who donated CZK 1 million to our research activities for 2022.

On the occasion of the International Angelman Day, we have prepared a press release summarizing our research (in Czech).