Publications

2020

  • Bautista-Niño PK, Portilla-Fernandez E, Rubio-Beltrán E, van der Linden JJ, de Vries R, van Veghel R, de Boer M, Durik M, Ridwan Y, Brandt R, Essers J, Menzies RI, Thomas R, de Bruin A, Duncker DJ, van Beusekom HMM, Ghanbari M, Hoeijmakers JHJ, Sedlacek R, Touyz RM, Montezano AC, van der Pluijm I, Danser AHJ, Haanes KA, Roks AJM Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction. Clin Sci (Lond) 2020 134(7): 727-746. [pubmed] [doi]
  • Budinska E, Gojda J, Heczkova M, Bratova M, Dankova H, Wohl P, Bastova H, Lanska V, Kostovcik M, Dastych M, Senkyrik M, Krizova J, Mraz M, Hradecky J, Hajslova J, Lenicek M, Podzimkova K, Chalupsky K, Sedlacek R, Cahova M Microbiome and Metabolome Profiles Associated With Different Types of Short Bowel Syndrome: Implications for Treatment. JPEN J Parenter Enteral Nutr 2020 44(1): 105-118. [pubmed] [doi]
  • Cacheiro P, Muñoz-Fuentes V, Murray SA, Dickinson ME, Bucan M, Nutter LMJ, Peterson KA, Haselimashhadi H, Flenniken AM, Morgan H, Westerberg H, Konopka T, Hsu CW, Christiansen A, Lanza DG, Beaudet AL, Heaney JD, Fuchs H, Gailus-Durner V, Sorg T, Prochazka J, Novosadova V, Lelliott CJ, Wardle-Jones H, Wells S, Teboul L, Cater H, Stewart M, Hough T, Wurst W, Sedlacek R, Adams DJ, Seavitt JR, Tocchini-Valentini G, Mammano F, Braun RE, McKerlie C, Herault Y, de Angelis MH, Mallon AM, Lloyd KCK, Brown SDM, Parkinson H, Meehan TF, Smedley D, , Human and mouse essentiality screens as a resource for disease gene discovery. Nat Commun 2020 11(1): 655. [pubmed] [doi]
  • Kralova J, Drobek A, Prochazka J, Spoutil F, Fabisik M, Glatzova D, Borna S, Pokorna J, Skopcova T, Angelisova P, Gregor M, Kovarik P, Sedlacek R, Brdicka T Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis. J Immunol 2020 204(6): 1607-1620. [pubmed] [doi]
  • Lloyd KCK, Adams DJ, Baynam G, Beaudet AL, Bosch F, Boycott KM, Braun RE, Caulfield M, Cohn R, Dickinson ME, Dobbie MS, Flenniken AM, Flicek P, Galande S, Gao X, Grobler A, Heaney JD, Herault Y, de Angelis MH, Lupski JR, Lyonnet S, Mallon AM, Mammano F, MacRae CA, McInnes R, McKerlie C, Meehan TF, Murray SA, Nutter LMJ, Obata Y, Parkinson H, Pepper MS, Sedlacek R, Seong JK, Shiroishi T, Smedley D, Tocchini-Valentini G, Valle D, Wang CL, Wells S, White J, Wurst W, Xu Y, Brown SDM The Deep Genome Project. Genome Biol 2020 21(1): 18. [pubmed] [doi]
  • Syding LA, Nickl P, Kasparek P, Sedlacek R CRISPR/Cas9 Epigenome Editing Potential for Rare Imprinting Diseases: A Review. Cells 2020 9(4). [pubmed] [doi]
  • Vobořil M, Brabec T, Dobeš J, Šplíchalová I, Březina J, Čepková A, Dobešová M, Aidarova A, Kubovčiak J, Tsyklauri O, Štěpánek O, Beneš V, Sedláček R, Klein L, Kolář M, Filipp D Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation. Nat Commun 2020 11(1): 2361. [pubmed] [doi]
  • Zhang T, Xie P, Dong Y, Liu Z, Zhou F, Pan D, Huang Z, Zhai Q, Gu Y, Wu Q, Tanaka N, Obata Y, Bradley A, Lelliott CJ, , Nutter LMJ, McKerlie C, Flenniken AM, Champy MF, Sorg T, Herault Y, Angelis MH, Durner VG, Mallon AM, Brown SDM, Meehan T, Parkinson HE, Smedley D, Lloyd KCK, Yan J, Gao X, Seong JK, Wang CL, Sedlacek R, Liu Y, Rozman J, Yang L, Xu Y High-throughput discovery of genetic determinants of circadian misalignment. PLoS Genet 2020 16(1): e1008577. [pubmed] [doi]
  • Ziak J, Weissova R, Jeřábková K, Janikova M, Maimon R, Petrasek T, Pukajova B, Kleisnerova M, Wang M, Brill MS, Kasparek P, Zhou X, Alvarez-Bolado G, Sedlacek R, Misgeld T, Stuchlik A, Perlson E, Balastik M CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling. EMBO Rep 2020 , e48512. [pubmed] [doi]

2019

  • Badiu Tișa I, Samașca G, Aldea C, Lupan I, Farcau D, Makovicky P Ganglioneuroblastoma in children. Neurol Sci 2019 40(9): 1985-1989. [pubmed] [doi]
  • Baláži A, Sirotkin AV, Földešiová M, Makovický P, Chrastinová Ľ, Makovický P, Chrenek P Green tea can supress rabbit ovarian functions in vitro and in vivo. Theriogenology 2019 127: 72-79. [pubmed] [doi]
  • Balounová J, Šplíchalová I, Dobešová M, Kolář M, Fišer K, Procházka J, Sedlacek R, Jurisicova A, Sung HK, Kořínek V, Alberich-Jorda M, Godin I, Filipp D Toll-like receptor 2 expression on c-kit cells tracks the emergence of embryonic definitive hematopoietic progenitors. Nat Commun 2019 10(1): 5176. [pubmed] [doi]
  • Bechynska K, Daskova N, Vrzackova N, Harant K, Heczková M, Podzimkova K, Bratova M, Dankova H, Berkova Z, Kosek V, Zelenka J, Hajslova J, Sedlacek R, Suttnar J, Hlavackova A, Bartonova L, Cahova M The effect of ω-3 polyunsaturated fatty acids on the liver lipidome, proteome and bile acid profile: parenteral versus enteral administration. Sci Rep 2019 9(1): 19097. [pubmed] [doi]
  • Burocziova M, Burdova K, Martinikova AS, Kasparek P, Kleiblova P, Danielsen SA, Borecka M, Jenikova G, Janečková L, Pavel J, Zemankova P, Schneiderova M, Schwarzova L, Ticha I, Sun XF, Jiraskova K, Liska V, Vodickova L, Vodicka P, Sedlacek R, Kleibl Z, Lothe RA, Korinek V, Macurek L Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon. Cell Death Dis 2019 10(11): 818. [pubmed] [doi]
  • Gresakova V, Novosadova V, Prochazkova M, Bhargava S, Jenickova I, Prochazka J, Sedlacek R Fam208a orchestrates interaction protein network essential for early embryonic development and cell division. Exp Cell Res 2019 382(1): 111437. [pubmed] [doi]
  • Gurumurthy CB, O'Brien AR, Quadros RM, Adams J, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D'Hont J, Dibb KM, Eudy JD, Gan L, Gao J, Gonzales A, Guntur AR, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majewska LA, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford AW, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y, Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation. Genome Biol 2019 20(1): 171. [pubmed] [doi]
  • Huebner K, Procházka J, Monteiro AC, Mahadevan V, Schneider-Stock R The activating transcription factor 2: an influencer of cancer progression. Mutagenesis 2019 34(5-6): 375-389. [pubmed] [doi]
  • Janeckova L, Kostovcikova K, Svec J, Stastna M, Strnad H, Kolar M, Hudcovic T, Stancikova J, Tureckova J, Baloghova N, Sloncova E, Galuskova K, Tlaskalova-Hogenova H, Korinek V Unique Gene Expression Signatures in the Intestinal Mucosa and Organoids Derived from Germ-Free and Monoassociated Mice. Int J Mol Sci 2019 20(7). [pubmed] [doi]
  • Kaiser K, Gyllborg D, Procházka J, Salašová A, Kompaníková P, Molina FL, Laguna-Goya R, Radaszkiewicz T, Harnoš J, Procházková M, Potěšil D, Barker RA, Casado ÁG, Zdráhal Z, Sedláček R, Arenas E, Villaescusa JC, Bryja V WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis. Nat Commun 2019 10(1): 1498. [pubmed] [doi]
  • Kaspar P, Prochazka J, Efenberkova M, Juhasz A, Novosadova V, Sedlacek R c-Myb regulates tumorigenic potential of embryonal rhabdomyosarcoma cells. Sci Rep 2019 9(1): 6342. [pubmed] [doi]
  • Kovalčíková J, Vrbacký M, Pecina P, Tauchmannová K, Nůsková H, Kaplanová V, Brázdová A, Alán L, Eliáš J, Čunátová K, Kořínek V, Sedlacek R, Mráček T, Houštěk J TMEM70 facilitates biogenesis of mammalian ATP synthase by promoting subunit c incorporation into the rotor structure of the enzyme. FASEB J 2019 33(12): 14103-14117. [pubmed] [doi]
  • Lustyk D, Kinský S, Ullrich KK, Yancoskie M, Kašíková L, Gergelits V, Sedlacek R, Chan YF, Odenthal-Hesse L, Forejt J, Jansa P Genomic Structure of Modifier of -Dependent Hybrid Male Sterility in Mice. Genetics 2019 213(3): 1047-1063. [pubmed] [doi]
  • Markova I, Miklankova D, Hüttl M, Kacer P, Skibova J, Kucera J, Sedlacek R, Kacerova T, Kazdova L, Malinska H The Effect of Lipotoxicity on Renal Dysfunction in a Nonobese Rat Model of Metabolic Syndrome: A Urinary Proteomic Approach. J Diabetes Res 2019 2019: 8712979. [pubmed] [doi]
  • Mihola O, Pratto F, Brick K, Linhartova E, Kobets T, Flachs P, Baker CL, Sedlacek R, Paigen K, Petkov PM, Camerini-Otero RD, Trachtulec Z Histone methyltransferase PRDM9 is not essential for meiosis in male mice. Genome Res 2019 29(7): 1078-1086. [pubmed] [doi]
  • Nováková M, Hampl M, Vrábel D, Procházka J, Petrezselyová S, Procházková M, Sedláček R, Kavková M, Zikmund T, Kaiser J, Juan HC, Fann MJ, Buchtová M, Kohoutek J Mouse Model of Congenital Heart Defects, Dysmorphic Facial Features and Intellectual Developmental Disorders as a Result of Non-functional CDK13. Front Cell Dev Biol 2019 7: 155. [pubmed] [doi]
  • Szczerkowska KI, Petrezselyova S, Lindovsky J, Palkova M, Dvorak J, Makovicky P, Fang M, Jiang C, Chen L, Shi M, Liu X, Zhang J, Kubik-Zahorodna A, Schuster B, Beck IM, Novosadova V, Prochazka J, Sedlacek R Myopia disease mouse models: a missense point mutation (S673G) and a protein-truncating mutation of the mimic human disease phenotype. Cell Biosci 2019 9: 21. [pubmed] [doi]
  • Taborska E, Pasulka J, Malik R, Horvat F, Jenickova I, Jelić Matošević Z, Svoboda P Restricted and non-essential redundancy of RNAi and piRNA pathways in mouse oocytes. PLoS Genet 2019 15(12): e1008261. [pubmed] [doi]
  • Vorlová B, Sedlák F, Kašpárek P, Šrámková K, Malý M, Zámečník J, Šácha P, Konvalinka J A novel PSMA/GCPII-deficient mouse model shows enlarged seminal vesicles upon aging. Prostate 2019 79(2): 126-139. [pubmed] [doi]
  • Yamano T, Dobeš J, Vobořil M, Steinert M, Brabec T, Ziętara N, Dobešová M, Ohnmacht C, Laan M, Peterson P, Benes V, Sedláček R, Hanayama R, Kolář M, Klein L, Filipp D Aire-expressing ILC3-like cells in the lymph node display potent APC features. J Exp Med 2019 216(5): 1027-1037. [pubmed] [doi]
  • Zikmund T, Kokavec J, Turkova T, Savvulidi F, Paszekova H, Vodenkova S, Sedlacek R, Skoultchi AI, Stopka T ISWI ATPase Smarca5 Regulates Differentiation of Thymocytes Undergoing β-Selection. J Immunol 2019 202(12): 3434-3446. [pubmed] [doi]

2018

  • Forte A, Grossi M, Bancone C, Cipollaro M, De Feo M, Hellstrand P, Persson L, Nilsson BO, Della Corte A Polyamine concentration is increased in thoracic ascending aorta of patients with bicuspid aortic valve. Heart Vessels 2018 33(3): 327-339. [pubmed] [doi]
  • Horn M, Zbodakova O, Kasparek P, Srp J, Haneckova R, Hradilek M, Mares M, Sedlacek R Profiling system for skin kallikrein proteolysis applied in gene-deficient mouse models. Biol Chem 2018 399(9): 1085-1089. [pubmed] [doi]
  • Horvat F, Fulka H, Jankele R, Malik R, Jun M, Solcova K, Sedlacek R, Vlahovicek K, Schultz RM, Svoboda P Role of Cnot6I in maternal mRNA turnover Life Sci Alliance 2018 1(4): e201800084. [pubmed] [doi]
  • Indrová M, Rossowska J, Pajtasz-Piasecka E, Mikyšková R, Richter J, Rosina J, Sedláček R, Fišerová A The role of immune cell subpopulations in the growth and rejection of TC-1/A9 tumors in novel mouse strains differing in the H2-D haplotype and NKC domain Oncology Letters 2018 15(3): 3594-3601. [pubmed] [doi]
  • Jirouskova M, Nepomucka K, Oyman-Eyrilmez G, Kalendova A, Havelkova H, Sarnova L, Chalupsky K, Schuster B, Benada O, Miksatkova P, Kuchar M, Fabian O, Sedlacek R, Wiche G, Gregor M Plectin controls biliary tree architecture and stability in cholestasis. J Hepatol 2018 68(5): 1006-1017. [pubmed] [doi]
  • Klein P, Sojka M, Kucera J, Matonohova J, Pavlik V, Nemec J, Kubickova G, Slavkovsky R, Szuszkiewicz K, Danek P, Rozkot M, Velebny V A porcine model of skin wound infected with a polybacterial biofilm. Biofouling 2018 34(2): 226-236. [pubmed] [doi]
  • Kral J, Korenkova V, Novosadova V, Langerova L, Schneiderova M, Liska V, Levy M, Veskrnova V, Spicak J, Opattova A, Jiraskova K, Vymetalkova V, Vodicka P, Slyskova J Expression profile of miR-17/92 cluster is predictive of treatment response in rectal cancer. Carcinogenesis 2018 39(11): 1359-1367. [pubmed] [doi]
  • Krupková M, Liška F, Kazdová L, Šedová L, Kábelová A, Křenová D, Křen V, Šeda O Single-Gene Congenic Strain Reveals the Effect of on Dexamethasone-Induced Insulin Resistance. Front Endocrinol (Lausanne) 2018 9: 185. [pubmed] [doi]
  • Magnen M, Elsässer BM, Zbodakova O, Kasparek P, Gueugnon F, Petit-Courty A, Sedlacek R, Goettig P, Courty Y Kallikrein-related peptidase 5 and seasonal influenza viruses, limitations of the experimental models for activating proteases. Biol Chem 2018 399(9): 1053-1064. [pubmed] [doi]
  • Makovický P, Chrenková M, Makovický P, Fľak P, Formelová Z, Novosadová V, Rajský M, Vannucci L The effect of selected feed mixtures on the duodenal morphology: comparison study. Physiol Res 2018 67(6): 955-962. [pubmed]
  • Mucksová J, Chalupský K, Plachý J, Kalina J, Rachacová P, Stanek O, Trefil P Simultaneous detection of chicken cytokines in plasma samples using the Bio-Plex assay. Poult Sci 2018 97(4): 1127-1133. [pubmed] [doi]
  • Newton AH, Spoutil F, Prochazka J, Black JR, Medlock K, Paddle RN, Knitlova M, Hipsley CA, Pask AJ Letting the 'cat' out of the bag: pouch young development of the extinct Tasmanian tiger revealed by X-ray computed tomography. R Soc Open Sci 2018 5(2): 171914. [pubmed] [doi]
  • Prochazkova M, Prochazka J, Marangoni P, Klein OD Bones, Glands, Ears and More: The Multiple Roles of FGF10 in Craniofacial Development. Front Genet 2018 9: 542. [pubmed] [doi]
  • Ramirez J, Lectez B, Osinalde N, Sivá M, Elu N, Aloria K, Procházková M, Perez C, Martínez-Hernández J, Barrio R, Šašková KG, Arizmendi JM, Mayor U Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome. Hum Mol Genet 2018 27(11): 1955-1971. [pubmed] [doi]
  • Rozman J, Rathkolb B, Oestereicher MA, Schütt C, Ravindranath AC, Leuchtenberger S, Sharma S, Kistler M, Willershäuser M, Brommage R, Meehan TF, Mason J, Haselimashhadi H, , Hough T, Mallon AM, Wells S, Santos L, Lelliott CJ, White JK, Sorg T, Champy MF, Bower LR, Reynolds CL, Flenniken AM, Murray SA, Nutter LMJ, Svenson KL, West D, Tocchini-Valentini GP, Beaudet AL, Bosch F, Braun RB, Dobbie MS, Gao X, Herault Y, Moshiri A, Moore BA, Kent Lloyd KC, McKerlie C, Masuya H, Tanaka N, Flicek P, Parkinson HE, Sedlacek R, Seong JK, Wang CL, Moore M, Brown SD, Tschöp MH, Wurst W, Klingenspor M, Wolf E, Beckers J, Machicao F, Peter A, Staiger H, Häring HU, Grallert H, Campillos M, Maier H, Fuchs H, Gailus-Durner V, Werner T, Hrabe de Angelis M Identification of genetic elements in metabolism by high-throughput mouse phenotyping. Nat Commun 2018 9(1): 288. [pubmed] [doi]
  • Sapega O, Mikyšková R, Bieblová J, Mrázková B, Hodný Z, Reiniš M Distinct phenotypes and 'bystander' effects of senescent tumour cells induced by docetaxel or immunomodulatory cytokines. Int J Oncol 2018 53(5): 1997-2009. [pubmed] [doi]
  • Seipold L, Altmeppen H, Koudelka T, Tholey A, Kasparek P, Sedlacek R, Schweizer M, Bär J, Mikhaylova M, Glatzel M, Saftig P In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15. Cell Mol Life Sci 2018 . [pubmed] [doi]
  • Sirotkin AV, Kadasi A, Stochmalova A, Balazi A, Földesiová M, Makovicky P, Chrenek P, Harrath AH Effect of turmeric on the viability, ovarian folliculogenesis, fecundity, ovarian hormones and response to luteinizing hormone of rabbits. Animal 2018 12(6): 1242-1249. [pubmed] [doi]
  • Šedová L, Školníková E, Hodúlová M, Včelák J, Šeda O, Bendlová B Expression profiling of Nme7 interactome in experimental models of metabolic syndrome. Physiol Res 2018 67(Supplementum 3): S543-S550. [pubmed]
  • Zarska M, Sramek M, Novotny F, Havel F, Babelova A, Mrazkova B, Benada O, Reinis M, Stepanek I, Musilek K, Bartek J, Ursinyova M, Novak O, Dzijak R, Kuca K, Proska J, Hodny Z Biological safety and tissue distribution of (16-mercaptohexadecyl)trimethylammonium bromide-modified cationic gold nanorods. Biomaterials 2018 154: 275-290. [pubmed] [doi]

2017

  • Bhargava S, Cox B, Polydorou C, Gresakova V, Korinek V, Strnad H, Sedlacek R, Epp TA, Chawengsaksophak K The epigenetic modifier Fam208a is required to maintain epiblast cell fitness. Sci Rep 2017 7(1): 9322. [pubmed] [doi]
  • Dong LF, Kovarova J, Bajzikova M, Bezawork-Geleta A, Svec D, Endaya B, Sachaphibulkij K, Coelho AR, Sebkova N, Ruzickova A, Tan AS, Kluckova K, Judasova K, Zamecnikova K, Rychtarcikova Z, Gopalan V, Andera L, Sobol M, Yan B, Pattnaik B, Bhatraju N, Truksa J, Stopka P, Hozak P, Lam AK, Sedlacek R, Oliveira PJ, Kubista M, Agrawal A, Dvorakova-Hortova K, Rohlena J, Berridge MV, Neuzil J Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells. Elife 2017 6. [pubmed] [doi]
  • Kasparek P, Ileninova Z, Zbodakova O, Kanchev I, Benada O, Chalupsky K, Brattsand M, Beck IM, Sedlacek R KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype. PLoS Genet 2017 13(1): e1006566. [pubmed] [doi]
  • Kim S, Prochazka J, Bush JO Live Imaging of Mouse Secondary Palate Fusion. J Vis Exp 2017 (125). [pubmed] [doi]
  • Kostiv U, Rajsiglová L, Luptáková D, Pluháček T, Vannucci L, Havlíček V, Engstová H, Jirák D, Šlouf M, Makovický P, Sedláček R, Horák D Biodistribution of upconversion/magnetic silica-coated NaGdF4:Yb3+/Er3+ nanoparticles in mouse models RSC Advances 2017 7(85): 45997-46006. [doi]
  • Makovický P, Matlach R, Makovický P, Švecová I, Samasca G Injury of the brain and liver capillaries in lethal car accidents Rom J Leg Med 2017 25: 351-358.
  • Makovicky P, Makovicky P, Lupan I, Samasca G, Sur G, Freeman HJ Perspective: Gluten-Free Products for Patients with Celiac Disease Should Not Contain Trace Levels. Adv Nutr 2017 8(3): 409-411. [pubmed] [doi]
  • Makovicky P, Tumova E, Volek Z, Makovicky P, Arnone JM, Svecova I, Samasca G The influence of food restriction on the small bowel: Does intensive short‑term food restriction lead to weight loss? Bratisl Lek Listy 2017 118(6): 361-365. [pubmed] [doi]
  • Mikyskova R, Indrova M, Stepanek I, Kanchev I, Bieblova J, Vosahlikova S, Moserova I, Truxova I, Fucikova J, Bartunkova J, Spisek R, Sedlacek R, Reinis M Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure inhibit prostate tumor growth in TRAMP mice. Oncoimmunology 2017 6(12): e1362528. [pubmed] [doi]
  • Naveau A, Zhang B, Meng B, Sutherland MT, Prochazkova M, Wen T, Marangoni P, Jones KB, Cox TC, Ganss B, Jheon AH, Klein OD Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor. J Bone Miner Res 2017 32(11): 2219-2231. [pubmed] [doi]
  • Prochazkova M, Häkkinen TJ, Prochazka J, Spoutil F, Jheon AH, Ahn Y, Krumlauf R, Jernvall J, Klein OD FGF signaling refines Wnt gradients to regulate the patterning of taste papillae. Development 2017 144(12): 2212-2221. [pubmed] [doi]
  • Samasca G, Lerner A, Girbovan A, Sur G, Lupan I, Makovicky P, Matthias T, Freeman HJ Challenges in gluten-free diet in coeliac disease: Prague consensus. Eur J Clin Invest 2017 47(5): 394-397. [pubmed] [doi]
  • Samasca G, Sur G, Lupan I, Makovicky P, Freeman HJ Challenges in the celiac disease diagnosis; Prague consensus. Gastroenterol Hepatol Bed Bench 2017 10(1): 1-2. [pubmed]
  • Seipold L, Damme M, Prox J, Rabe B, Kasparek P, Sedlacek R, Altmeppen H, Willem M, Boland B, Glatzel M, Saftig P Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein. Biochim Biophys Acta 2017 1864(1): 217-230. [pubmed] [doi]
  • Skopova K, Tomalova B, Kanchev I, Rossmann P, Svedova M, Adkins I, Bibova I, Tomala J, Masin J, Guiso N, Osicka R, Sedlacek R, Kovar M, Sebo P Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis. Infect Immun 2017 85(6). [pubmed] [doi]
  • Šeda O, Liška F, Pravenec M, Vernerová Z, Kazdová L, Křenová D, Zídek V, Šedová L, Krupková M, Křen V Connexin 50 mutation lowers blood pressure in spontaneously hypertensive rat. Physiol Res 2017 66(1): 15-28. [pubmed]
  • Šeda O, Šedová L, Včelák J, Vaňková M, Liška F, Bendlová B ZBTB16 and metabolic syndrome: a network perspective. Physiol Res 2017 66(Supplementum 3): S357-S365. [pubmed]
  • Wald T, Spoutil F, Osickova A, Prochazkova M, Benada O, Kasparek P, Bumba L, Klein OD, Sedlacek R, Sebo P, Prochazka J, Osicka R Intrinsically disordered proteins drive enamel formation via an evolutionarily conserved self-assembly motif. Proc Natl Acad Sci U S A 2017 114(9): E1641-E1650. [pubmed] [doi]
  • Žbodáková O, Chalupský K, Turečková J, Sedláček R Metalloproteinases in liver fibrosis: current insights Metalloproteinases In Medicine 2017 4: 25 - 35.

2016

  • Brauer R, Turečková J, Kanchev I, Khoylou M, Škarda J, Procházka J, Spoutil F, Beck IM, Žbodáková O, Kašpárek P, Kořínek V, Chalupský K, Karhu T, Herzig KH, Hajduch M, Gregor M, Sedláček R MMP-19 deficiency causes aggravation of colitis due to defects in innate immune cell function. Mucosal Immunol 2016 9(4): 974-85. [pubmed] [doi]
  • Cole JB, Manyama M, Kimwaga E, Mathayo J, Larson JR, Liberton DK, Lukowiak K, Ferrara TM, Riccardi SL, Li M, Mio W, Prochazkova M, Williams T, Li H, Jones KL, Klein OD, Santorico SA, Hallgrimsson B, Spritz RA Genomewide Association Study of African Children Identifies Association of SCHIP1 and PDE8A with Facial Size and Shape. PLoS Genet 2016 12(8): e1006174. [pubmed] [doi]
  • Du W, Prochazka J, Prochazkova M, Klein OD Expression of FGFs during early mouse tongue development. Gene Expr Patterns 2016 20(2): 81-7. [pubmed] [doi]
  • Dvořák J, Fajtová P, Ulrychová L, Leontovyč A, Rojo-Arreola L, Suzuki BM, Horn M, Mareš M, Craik CS, Caffrey CR, O'Donoghue AJ Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles. Biochimie 2016 122: 99-109. [pubmed] [doi]
  • Fišerová A, Richter J, Čapková K, Bieblová J, Mikyšková R, Reiniš M, Indrová M Resistance of novel mouse strains different in MHC class I and the NKC domain to the development of experimental tumors. Int J Oncol 2016 49(2): 763-72. [pubmed] [doi]
  • Hodny Z, Reinis M, Hubackova S, Vasicova P, Bartek J Interferon gamma/NADPH oxidase defence system in immunity and cancer OncoImmunology 2016 5(2): 1-7. [doi]
  • Hubackova S, Kucerova A, Michlits G, Kyjacova L, Reinis M, Korolov O, Bartek J, Hodny Z IFNγ induces oxidative stress, DNA damage and tumor cell senescence via TGFβ/SMAD signaling-dependent induction of Nox4 and suppression of ANT2. Oncogene 2016 35(10): 1236-49. [pubmed] [doi]
  • Janečková L, Fafílek B, Krausová M, Horázná M, Vojtěchová M, Alberich-Jorda M, Šloncová E, Galušková K, Sedláček R, Anděrová M, Kořínek V Wnt Signaling Inhibition Deprives Small Intestinal Stem Cells of Clonogenic Capacity. Genesis 2016 54(3): 101-14. [pubmed] [doi]
  • Jankovicova J, Frolikova M, Sebkova N, Simon M, Cupperova P, Lipcseyova D, Michalkova K, Horovska L, Sedlacek R, Stopka P, Antalikova J, Dvorakova-Hortova K Characterization of tetraspanin protein CD81 in mouse spermatozoa and bovine gametes. Reproduction 2016 152(6): 785-793. [pubmed] [doi]
  • Kasparek P, Ileninova Z, Haneckova R, Kanchev I, Jenickova I, Sedlacek R A viable mouse model for Netherton syndrome based on mosaic inactivation of the Spink5 gene. Biol Chem 2016 397(12): 1287-1292. [pubmed] [doi]
  • Kubik-Zahorodna A, Schuster B, Kanchev I, Sedláček R Neurological Deficits of an Rps19(Arg67del) Model of Diamond-Blackfan Anaemia. Folia Biol (Praha) 2016 62(4): 139-47. [pubmed]
  • Makovicky P, Tumova E, Volek Z, Makovicky P, Sedlacek R Relationships between variable time, percentage of food restriction and liver histology: which alternative is the best for non-alcoholic fatty liver disease (NAFLD) prevention? Histol Histopathol 2016 31(10): 1123-30. [pubmed] [doi]
  • Mikyšková R, Štěpánek I, Indrová M, Bieblová J, Šímová J, Truxová I, Moserová I, Fučíková J, Bartůňková J, Špíšek R, Reiniš M Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure induce strong immune responses and display therapeutic effects both in murine TC-1 and TRAMP-C2 tumors when combined with docetaxel chemotherapy. Int J Oncol 2016 48(3): 953-64. [pubmed] [doi]
  • Moudra A, Hubackova S, Machalova V, Vancurova M, Bartek J, Reinis M, Hodny Z, Jonasova A Dynamic alterations of bone marrow cytokine landscape of myelodysplastic syndromes patients treated with 5-azacytidine. Oncoimmunology 2016 5(10): e1183860. [pubmed] [doi]
  • Müller M, Wetzel S, Köhn-Gaone J, Chalupsky K, Lüllmann-Rauch R, Barikbin R, Bergmann J, Wöhner B, Zbodakova O, Leuschner I, Martin G, Tiegs G, Rose-John S, Sedlacek R, Tirnitz-Parker JE, Saftig P, Schmidt-Arras D A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis. Oncotarget 2016 7(14): 17431-41. [pubmed] [doi]
  • Roque A, Petrezsélyová S, Serra-Cardona A, Ariño J Genome-wide recruitment profiling of transcription factor Crz1 in response to high pH stress. BMC Genomics 2016 17: 662. [pubmed] [doi]
  • Simova J, Sapega O, Imrichova T, Stepanek I, Kyjacova L, Mikyskova R, Indrova M, Bieblova J, Bubenik J, Bartek J, Hodny Z, Reinis M Tumor growth accelerated by chemotherapy-induced senescent cells is suppressed by treatment with IL-12 producing cellular vaccines. Oncotarget 2016 7(34): 54952-54964. [pubmed] [doi]
  • Šeda O, Křenová D, Oliyarnyk O, Šedová L, Krupková M, Liška F, Chylíková B, Kazdová L, Křen V Heterozygous connexin 50 mutation affects metabolic syndrome attributes in spontaneously hypertensive rat. Lipids Health Dis 2016 15(1): 199. [pubmed] [doi]
  • Šedová L, Pravenec M, Křenová D, Kazdová L, Zídek V, Krupková M, Liška F, Křen V, Šeda O Isolation of a Genomic Region Affecting Most Components of Metabolic Syndrome in a Chromosome-16 Congenic Rat Model. PLoS One 2016 11(3): e0152708. [pubmed] [doi]
  • Vernerova L, Spoutil F, Vlcek M, Krskova K, Penesova A, Meskova M, Marko A, Raslova K, Vohnout B, Rovensky J, Killinger Z, Jochmanova I, Lazurova I, Steiner G, Smolen J, Imrich R A Combination of CD28 (rs1980422) and IRF5 (rs10488631) Polymorphisms Is Associated with Seropositivity in Rheumatoid Arthritis: A Case Control Study. PLoS One 2016 11(4): e0153316. [pubmed] [doi]
  • Vrbacký M, Kovalčíková J, Chawengsaksophak K, Beck IM, Mráček T, Nůsková H, Sedmera D, Papoušek F, Kolář F, Sobol M, Hozák P, Sedlacek R, Houštěk J Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice. Hum Mol Genet 2016 . [pubmed] [doi]

2015

  • Balastik M, Zhou XZ, Alberich-Jorda M, Weissova R, Žiak J, Pazyra-Murphy MF, Cosker KE, Machonova O, Kozmikova I, Chen CH, Pastorino L, Asara JM, Cole A, Sutherland C, Segal RA, Lu KP Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons. Cell Rep 2015 13(4): 812-28. [pubmed] [doi]
  • Beck IM, Sedlacek R TT2014 meeting report on the 12th Transgenic Technology meeting in Edinburgh: new era of transgenic technologies with programmable nucleases in the foreground. Transgenic Res 2015 24(1): 179-83. [pubmed] [doi]
  • Chalupsky K, Kračun D, Kanchev I, Bertram K, Görlach A Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase. Antioxid Redox Signal 2015 23(14): 1076-91. [pubmed] [doi]
  • Kaspar P, Zikova M, Bartunek P, Sterba J, Strnad H, Kren L, Sedlacek R The Expression of c-Myb Correlates with the Levels of Rhabdomyosarcoma-specific Marker Myogenin. Sci Rep 2015 5: 15090. [pubmed] [doi]
  • Meehan TF, Chen CK, Koscielny G, Relac M, Wilkinson P, Flicek P, Parkinson H, Castro A, Fessele S, Steinkamp R, Hagn M, Raess M, de Angelis MH, Bottomley J, Ramirez-Solis R, Smedley D, Ball S, Blake A, Fray M, Kenyon J, Mallon AM, Brown S, Massimi M, Matteoni R, Tocchini-Valentini G, Herault Y, Kollias G, Fleming A, Ulfhake B, Demengeot J, Fremond C, Bosch F, Montoliu L, Soininen R, Schughart K, Brakebusch C, Sedlacek R, Rülicke T, McKerlie C, Malissen B, Iraqi F, Jonkers J, Russig H, Huylebroeck D INFRAFRONTIER--providing mutant mouse resources as research tools for the international scientific community. Nucleic Acids Res 2015 43(Database issue): D1171-5. [pubmed] [doi]
  • Prochazka J, Prochazkova M, Du W, Spoutil F, Tureckova J, Hoch R, Shimogori T, Sedlacek R, Rubenstein JL, Wittmann T, Klein OD Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis. Dev Cell 2015 35(6): 713-24. [pubmed] [doi]
  • Stancikova J, Krausova M, Kolar M, Fafilek B, Svec J, Sedlacek R, Neroldova M, Dobes J, Horazna M, Janeckova L, Vojtechova M, Oliverius M, Jirsa M, Korinek V NKD1 marks intestinal and liver tumors linked to aberrant Wnt signaling. Cell Signal 2015 27(2): 245-56. [pubmed] [doi]
  • Wu D, Mandal S, Choi A, Anderson A, Prochazkova M, Perry H, Gil-Da-Silva-Lopes VL, Lao R, Wan E, Tang PL, Kwok PY, Klein O, Zhuan B, Slavotinek AM DLX4 is associated with orofacial clefting and abnormal jaw development. Hum Mol Genet 2015 24(15): 4340-52. [pubmed] [doi]

2014

  • Cervinková M, Horák P, Kanchev I, Matěj R, Fanta J, Sequens R, Kašpárek P, Sarnová L, Turečková J, Sedláček R Differential expression and processing of matrix metalloproteinase 19 marks progression of gastrointestinal diseases. Folia Biol (Praha) 2014 60(3): 113-22. [pubmed]
  • Flemr M, Moravec M, Libova V, Sedlacek R, Svoboda P Lin28a is dormant, functional, and dispensable during mouse oocyte-to-embryo transition. Biol Reprod 2014 90(6): 131. [pubmed] [doi]
  • Gregor M, Osmanagic-Myers S, Burgstaller G, Wolfram M, Fischer I, Walko G, Resch GP, Jörgl A, Herrmann H, Wiche G Mechanosensing through focal adhesion-anchored intermediate filaments. FASEB J 2014 28(2): 715-29. [pubmed] [doi]
  • Harten SK, Bruxner TJ, Bharti V, Blewitt M, Nguyen TM, Whitelaw E, Epp T The first mouse mutants of D14Abb1e (Fam208a) show that it is critical for early development. Mamm Genome 2014 25(7-8): 293-303. [pubmed] [doi]
  • Chalupnikova K, Solc P, Sulimenko V, Sedlacek R, Svoboda P An oocyte-specific ELAVL2 isoform is a translational repressor ablated from meiotically competent antral oocytes. Cell Cycle 2014 13(7): 1187-200. [pubmed] [doi]
  • Kasparek P, Krausova M, Haneckova R, Kriz V, Zbodakova O, Korinek V, Sedlacek R Efficient gene targeting of the Rosa26 locus in mouse zygotes using TALE nucleases. FEBS Lett 2014 588(21): 3982-8. [pubmed] [doi]
  • Liss A, Ooi CH, Zjablovskaja P, Benoukraf T, Radomska HS, Ju C, Wu M, Balaštík M, Delwel R, Brdička T, Tan P, Tenen DG, Alberich-Jorda M The gene signature in CCAAT-enhancer-binding protein α dysfunctional acute myeloid leukemia predicts responsiveness to histone deacetylase inhibitors. Haematologica 2014 99(4): 697-705. [pubmed] [doi]
  • Prukova D, Ileninova Z, Antosova B, Kasparek P, Gregor M, Sedlacek R Transgenic reporter mice with promoter region of murine LRAT specifically marks lens and meiosis spermatocytes. Physiol Res 2014 . [pubmed]
  • Sperrhacke M, Fischer J, Wu Z, Klünder S, Sedlacek R, Schroeder JM, Meyer-Hoffert U, Reiss K SPINK9 stimulates metalloprotease/EGFR-dependent keratinocyte migration via purinergic receptor activation. J Invest Dermatol 2014 134(6): 1645-54. [pubmed] [doi]

2013

  • Buryova H, Chalupský K, Žbodáková O, Kanchev I, Jiroušková M, Gregor M, Sedláček R Liver protective effect of ursodeoxycholic acid includes regulation of ADAM17 activity. BMC Gastroenterol 2013 13(1): 155. [pubmed] [doi]
  • Daxinger L, Harten S, Oey H, Epp T, Isbel L, Huang E, Whitelaw N, Apedaile A, Sorolla A, Yong J, Bharti V, Sutton J, Ashe A, Pang ZY, Wallace N, Gerhardt DJ, Blewitt ME, Jeddeioh JA, Whitelaw E An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse. Genome Biol 2013 14(9): R96. [pubmed] [doi]
  • Fafilek B, Krausova M, Vojtechova M, Pospichalova V, Tumova L, Sloncova E, Huranova M, Stancikova J, Hlavata A, Svec J, Sedlacek R, Luksan O, Oliverius M, Voska L, Jirsa M, Paces J, Kolar M, Krivjanska M, Klimesova K, Tlaskalova-Hogenova H, Korinek V Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells. Gastroenterology 2013 144(2): 381-91. [pubmed] [doi]
  • Flemr M, Malik R, Franke V, Nejepinska J, Sedlacek R, Vlahovicek K, Svoboda P A retrotransposon-driven dicer isoform directs endogenous small interfering RNA production in mouse oocytes. Cell 2013 155(4): 807-16. [pubmed] [doi]
  • Chalupský K, Kanchev I, Žbodáková O, Buryová H, Jiroušková M, Kořínek V, Gregor M, Sedláček R ADAM10/17-dependent release of soluble c-Met correlates with hepatocellular damage. Folia Biol (Praha) 2013 59(2): 76-86. [pubmed]
  • Klimova L, Lachova J, Machon O, Sedlacek R, Kozmik Z Generation of mRx-Cre transgenic mouse line for efficient conditional gene deletion in early retinal progenitors. PLoS One 2013 8(5): e63029. [pubmed] [doi]
  • Youngson NA, Epp T, Roberts AR, Daxinger L, Ashe A, Huang E, Lester KL, Harten SK, Kay GF, Cox T, Matthews JM, Chong S, Whitelaw E No evidence for cumulative effects in a Dnmt3b hypomorph across multiple generations. Mamm Genome 2013 24(5-6): 206-17. [pubmed] [doi]

2012

  • Alberich-Jordà M, Wouters B, Balastik M, Shapiro-Koss C, Zhang H, Di Ruscio A, Radomska HS, Ebralidze AK, Amabile G, Ye M, Zhang J, Lowers I, Avellino R, Melnick A, Figueroa ME, Valk PJ, Delwel R, Tenen DG C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia. J Clin Invest 2012 122(12): 4490-504. [pubmed] [doi]
  • Gao L, Siu KL, Chalupsky K, Nguyen A, Chen P, Weintraub NL, Galis Z, Cai H Role of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation: treatment with folic acid. Hypertension 2012 59(1): 158-66. [pubmed] [doi]
  • Jirouskova M, Zbodakova O, Gregor M, Chalupsky K, Sarnova L, Hajduch M, Ehrmann J, Jirkovska M, Sedlacek R Hepatoprotective Effect of MMP-19 Deficiency in a Mouse Model of Chronic Liver Fibrosis. PLoS One 2012 7(10): e46271. [pubmed] [doi]
  • Kasparek P, Krenek P, Buryova H, Suchanova S, Beck IM, Sedlacek R Transgenic mouse model expressing tdTomato under involucrin promoter as a tool for analysis of epidermal differentiation and wound healing. Transgenic Res 2012 21(3): 683-9. [pubmed] [doi]
  • Kollmus H, Post R, Brielmeier M, Fernández J, Fuchs H, McKerlie C, Montoliu L, Otaegui PJ, Rebelo M, Riedesel H, Ruberte J, Sedlacek R, de Angelis MH, Schughart K Structural and functional concepts in current mouse phenotyping and archiving facilities. J Am Assoc Lab Anim Sci 2012 51(4): 418-35. [pubmed]
  • Laššuthová P, Gregor M, Sarnová L, Machalová E, Sedláček R, Seeman P Clinical, In Silico, and Experimental Evidence for Pathogenicity of Two Novel Splice Site Mutations in the SH3TC2 Gene. J Neurogenet 2012 26(3-4): 413-20. [pubmed] [doi]

2011

  • Brauer R, Beck IM, Roderfeld M, Roeb E, Sedlacek R Matrix metalloproteinase-19 inhibits growth of endothelial cells by generating angiostatin-like fragments from plasminogen. BMC Biochem 2011 12: 38. [pubmed] [doi]
  • Chan KC, Ko JM, Lung HL, Sedlacek R, Zhang ZF, Luo DZ, Feng ZB, Chen S, Chen H, Chan KW, Tsao SW, Chua DT, Zabarovsky ER, Stanbridge EJ, Lung ML Catalytic activity of Matrix metalloproteinase-19 is essential for tumor suppressor and anti-angiogenic activities in nasopharyngeal carcinoma. Int J Cancer 2011 129(8): 1826-37. [pubmed] [doi]
  • Reiss K, Meyer-Hoffert U, Fischer J, Sperrhacke M, Wu Z, Dimitrieva O, Krenek P, Suchanova S, Buryova H, Brauer R, Sedlacek R Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2. Exp Dermatol 2011 20(11): 905-10. [pubmed] [doi]

2010

  • Lettau I, Hattermann K, Held-Feindt J, Brauer R, Sedlacek R, Mentlein R Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells. J Neuropathol Exp Neurol 2010 69(3): 215-23. [pubmed] [doi]
  • Lokossou AA, Rietman H, Wang M, Krenek P, van der Schoot H, Henken B, Hoekstra R, Vleeshouwers VG, van der Vossen EA, Visser RG, Jacobsen E, Vosman B Diversity, distribution, and evolution of Solanum bulbocastanum late blight resistance genes. Mol Plant Microbe Interact 2010 23(9): 1206-16. [pubmed] [doi]
  • Müller M, Beck IM, Gadesmann J, Karschuk N, Paschen A, Proksch E, Djonov V, Reiss K, Sedlacek R MMP19 is upregulated during melanoma progression and increases invasion of melanoma cells. Mod Pathol 2010 23(4): 511-21. [pubmed] [doi]
  • Sarnova L, Malik R, Sedlacek R, Svoboda P Shortcomings of short hairpin RNA-based transgenic RNA interference in mouse oocytes. J Negat Results Biomed 2010 9: 8. [pubmed] [doi]

2008

  • Beck IM, Rückert R, Brandt K, Mueller MS, Sadowski T, Brauer R, Schirmacher P, Mentlein R, Sedlacek R MMP19 is essential for T cell development and T cell-mediated cutaneous immune responses. PLoS One 2008 3(6): e2343. [pubmed] [doi]