We are enhancing our
understanding
of the genetic basis for
human diseases

Genetically modified mouse models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. Crucial for this technology is the ability to control the expression of genes of interest. It is possible to increase or decrease gene expression, or eliminate the expression of a gene completely.

Transgenic and gene knockout/knockin technologies have become important experimental tools for assigning functions to genes at the level of whole complexity of organism, creating models of genetic disorders, evaluating effects drugs and toxins, thus helping to answer fundamental issues in basic and applied research.

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What can we help you with

Phenotyping

The genomes of humans, mice and other species have been completely sequenced, yet the knowledge of genome sequences as such does not shed light on questions concerning the functions of these sequences. In order to describe biological functions of a gene, an informative 

Research

The research program is focused onto functional genomics using genetically engineered models and is closely connected to the infrastructure of Czech Centre for Phenogenomics that provides the project indispensable core facilities. 

Model generation services

Genetically modified mouse models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. Crucial for this technology is the ability to control the expression of genes of interest. It is possible to increase or decrease gene expression, or eliminate the expression of a gene completely. 

Education

The Czech Centre for Phenogenomics organizes seminars, workshops and trainings focused on advanced phenotyping techniques, genome manipulation, microscopy and data analysis. Participants get theoretical and practical knowledge from the expert instructors 

Latest News

26. 01. 2023

Thanks to mice, scientists at the Czech Academy of Sciences identified, for example, the gene behind retinal degeneration

The Czech Academy of Sciences celebrates 70 years. Genetically modified mouse models help reveal the causes of human diseases, explains scientist Radislav Sedláček. Just turn off a gene in a mouse and you will learn which gene could be responsible for one of the diseases in humans. In the next part of our series on…

23. 01. 2023

“Gene Age” travelling lecture tour in 2022 – summary report

“Gene Age” is an accompanying travelling lecture series of the AV21 Strategy research programme “Towards precision medicine and gene therapy “ In December 2022, the Czech Centre for Phenogenomics (CCP) at the Institute of Molecular Genetics of the Czech Academy of Sciences organized a traveling series of lectures “The Gene Age” on the topic of…

18. 11. 2022

ISIDORe new calls for transnational access open

We would like to inform you about a new range of transnational access calls recently launched under the ISIDORe project. These are free-of-charge open calls on specific pathogens and related-services accessible to researchers in the EU and abroad. Details about the open calls are available at ISIDORe website. Find out more about how INFRAFRONTIER contributes…

About Czech Centre for Phenogenomics

Genetically modified mouse models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. Crucial for this technology is the ability to control the expression of genes of interest. It is possible to increase or decrease gene expression, or eliminate the expression of a gene completely.

Transgenic and gene knockout/knockin technologies have become important experimental tools for assigning functions to genes at the level of whole complexity of organism, creating models of genetic disorders, evaluating effects drugs and toxins, thus helping to answer fundamental issues in basic and applied research.

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Standard services Clinical Chemistry

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Custom services Multiplex Immunoassays

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