We are enhancing our
understanding
of the genetic basis for
human diseases

Genetically modified mouse models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. Crucial for this technology is the ability to control the expression of genes of interest. It is possible to increase or decrease gene expression, or eliminate the expression of a gene completely.

Transgenic and gene knockout/knockin technologies have become important experimental tools for assigning functions to genes at the level of whole complexity of organism, creating models of genetic disorders, evaluating effects drugs and toxins, thus helping to answer fundamental issues in basic and applied research.

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What can we help you with

Phenotyping

The genomes of humans, mice and other species have been completely sequenced, yet the knowledge of genome sequences as such does not shed light on questions concerning the functions of these sequences. In order to describe biological functions of a gene, an informative 

Research

The research program is focused onto functional genomics using genetically engineered models and is closely connected to the infrastructure of Czech Centre for Phenogenomics that provides the project indispensable core facilities. 

Model generation services

Genetically modified mouse models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. Crucial for this technology is the ability to control the expression of genes of interest. It is possible to increase or decrease gene expression, or eliminate the expression of a gene completely. 

Education

The Czech Centre for Phenogenomics organizes seminars, workshops and trainings focused on advanced phenotyping techniques, genome manipulation, microscopy and data analysis. Participants get theoretical and practical knowledge from the expert instructors 

Latest News

04. 08. 2020

Submit your abstract for the 2nd CCP Phenogenomics Conference

Main topics: Therapeutics, therapeutic target and preclinical evaluationEnvironmental stressors in health / Bioinformatics in gene networks and therapeutics assessment / Immunity /Genetic base of diseases

31. 07. 2020

Open call for collaborative projects

The main objective of this open call is to facilitate access for the wider biomedical research community to a unique phenotyping infrastructure. The CCP will provide the following services free of charge: A) Gene Nomination & Primary Phenotyping B) Secondary Phenotyping / Line distribution For more details go the Open calls.

08. 07. 2020

CCP @ “Science and research in the fight against the SARS-CoV-2 / Covid-19 pandemic”

The Czech Centre for Phenogenomics participates in the conference “Science and research in the fight against the SARS-CoV-2 / Covid-19 pandemic mouse models for studying infections such as SARS-CoV-2 and their treatments – Research infrastructure as part of critical infrastructure of the state”. CCP will be represented by Radislav Sedlacek who will deliver a presentation…

About Czech Centre for Phenogenomics

Genetically modified mouse models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. Crucial for this technology is the ability to control the expression of genes of interest. It is possible to increase or decrease gene expression, or eliminate the expression of a gene completely.

Transgenic and gene knockout/knockin technologies have become important experimental tools for assigning functions to genes at the level of whole complexity of organism, creating models of genetic disorders, evaluating effects drugs and toxins, thus helping to answer fundamental issues in basic and applied research.

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Standard services Clinical Chemistry

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Custom services Multiplex Immunoassays

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