We are enhancing our
understanding
of the genetic basis for
human diseases

Genetically modified mouse models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. Crucial for this technology is the ability to control the expression of genes of interest. It is possible to increase or decrease gene expression, or eliminate the expression of a gene completely.

Transgenic and gene knockout/knockin technologies have become important experimental tools for assigning functions to genes at the level of whole complexity of organism, creating models of genetic disorders, evaluating effects drugs and toxins, thus helping to answer fundamental issues in basic and applied research.

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What can we help you with

Phenotyping

The genomes of humans, mice and other species have been completely sequenced, yet the knowledge of genome sequences as such does not shed light on questions concerning the functions of these sequences. In order to describe biological functions of a gene, an informative 

Research

The research program is focused onto functional genomics using genetically engineered models and is closely connected to the infrastructure of Czech Centre for Phenogenomics that provides the project indispensable core facilities. 

Model generation services

Genetically modified mouse models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. Crucial for this technology is the ability to control the expression of genes of interest. It is possible to increase or decrease gene expression, or eliminate the expression of a gene completely. 

Education

The Czech Centre for Phenogenomics organizes seminars, workshops and trainings focused on advanced phenotyping techniques, genome manipulation, microscopy and data analysis. Participants get theoretical and practical knowledge from the expert instructors 

Latest News

07. 10. 2020

Nobel Prize in Chemistry 2020 – CRISPR/Cas9 genetic scissors

The Nobel Prize in Chemistry 2020 was awarded jointly to Emmanuelle Charpentier and Jennifer A. Doudna for the development of a method for genome editing. For more information visit the Nobel Prize website. Interested in using CRISPR/Cas9 technology? Our proficient team of Transgenic and Archiving Module provides services from design to delivery of a mutant…

23. 09. 2020

European Research Initiative for Pre-clinical, Environmental, Virtual Integrative Assessments, and Therapies

The PREVALENT initiative brings together 15 partners across 9 European countries who have joined forces to implement a novel European Research Infrastructure for pre-clinical, environmental, virtual integrative assessments, and therapeutics development. PREVALENT integrates essential pre-clinical research platforms ranging from pre-clinical evaluations of drugs, disease modelling using precision animal models, medicinal chemistry, and the assessment of…

23. 09. 2020

2nd CCP Phenogenomics Conference 2020 in Numbers

The 2nd CCP Phenogenomics Conference took place on 17 – 18 September 2020 at BIOCEV campus in Vestec as an on-site event with participation of high profile remote international speakers. The conference was attended by 90 on-site participants, 17 remote speakers and the online streaming was watched by 30 participants on average. Topics: Therapeutics, therapeutic…

About Czech Centre for Phenogenomics

Genetically modified mouse models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. Crucial for this technology is the ability to control the expression of genes of interest. It is possible to increase or decrease gene expression, or eliminate the expression of a gene completely.

Transgenic and gene knockout/knockin technologies have become important experimental tools for assigning functions to genes at the level of whole complexity of organism, creating models of genetic disorders, evaluating effects drugs and toxins, thus helping to answer fundamental issues in basic and applied research.

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Standard services Clinical Chemistry

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Custom services Multiplex Immunoassays

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