With staff around 100 people the CCP is one of the largest national research infrastructures in the field of biomedicine. The center is located in the municipality of Vestec south of the capital city of Prague in the Czech Republic. Set on the campus of the BIOCEV, CCP is a state of the art facility combining the generation, phenotyping and archiving of rodent strains. As a member of the International Mouse Phenotyping Consortium (IMPC) and INFRAFRONTIER, CCP is dedicated to the goal of systematic genome-wide phenotyping project of knock-out mice in order to provide the broader research community with a lasting resource of mammalian gene function

The CCP is part of Institute of Molecular Genetics of the Academy of Sciences of the Czech Republic (IMG), leading Czech research institute in the field of molecular biology and genetics.

For further information please contact project coordinator Mr. Libor Daněk via email libor.danek@img.cas.cz.

The applications in English including letter of interest & structured CV and (if relevant) list of publications and letters of reference should be sent via above-mentioned email as well.

We offer a stimulating and challenging work environment, opportunities for career advancement, and competitive salary. The positions are available immediately (if not stated otherwise) for an initial fixed-term contract (1 year), with possible longer-term extension upon demonstrated proficiency.

We thank all who apply for their interest; however, only those candidates who are considered for an interview will be contacted. All vacancies are open until filled or otherwise stated.

All positions have place of work in BIOCEV campus in Vestec in close vicinity to Prague except otherwise stated.

Nabídka pracovních pozic ve zvěřinci ÚMG níže na stránce.

Currently we are seeking candidates to following positions:

Open Position

PhD position in genome editing technologies (ESR) for the Marie Skłodowska Curie ETN-training network “Improving Genome Editing Efficiency” (IMGENE).

DURATION: 36 Months
WEBSITE: www.imgene.ku.dk

Project Title:
New transgenic models of rare diseases generated using programmable nucleases:
CRISPR-Cas9 based genome editing of germline cells

The group and our research:
The position is available in the department of Transgenic Models of diseases, which closely cooperates with the Czech Centre for Phenogenomics. The successful applicant will especially cooperate with the Transgenic and Archiving Module of CCP where the new targeting technologies will be developed. The analysis of the new models will be performed in cooperation with the team of Phenotyping Module of CCP.  

Main Objective and expected results:
The main objective is the improve CRISPR genome editing efficiency in mice by development and optimization of targeting technologies employing in vivo electroporation, manipulation of spermatogonial stem cells, and other methods. Besides the technology development, mouse/rat models for several selected human rare disease models will be generated and their phenotype analysed. The expected results include new or optimized technologies and protocols for in vivo/ex vivo targeting using CRISPR/Cas system and new models for rare diseases.

Work location and supervisor name:
Institute of Molecular Genetics, the Czech Centre of Phenogenomics
Prumyslova 595,
252 50 Vestec, Czech Republic
Supervisor: Assoc. Prof. Radislav Sedlacek, PhD

Required Skills/qualification:
We are looking for a highly motivated and enthusiastic candidate with the following qualifications:
– A Master of Science in biology or biotechnology or similar field
– Experience in biochemistry, molecular biology, genetics and cell culture is expected
– General knowledge about biology, physiology and reproduction will of advantage
– Excellent communication skills in English are requested

Project background and goal:
CRISPR genome editing technology is considered to become the greatest technological improvement in biomedical research since the invention of the polymerase chain reaction 25 years ago and pharmaceutical companies as well as academic research are eager to apply it. However, the efficiency of introducing defined changes into the genome by CRISPR is still low, currently limiting its application in basic research, industry and gene therapy. The IMGENE consortium unites expert European research groups of academia and industry to address by innovative and complementary approaches the low efficiency of precise genome editing using CRISPR technology. Combining complementary knowledge on protein chemistry, molecular biology, cellular biology, viral vectors, transgenic mice, gene therapy, and bioinformatics present in the network, IMGENE will establish novel tools and protocols for improved CRISPR genome editing efficiency that will be of immediate benefit for health and life science research, the pharmaceutical industry, and the application of gene therapy. In addition, IMGENE addresses crucial ethical questions related to the application of genome editing technology in animals, plants, and humans, which have to be solved to gain acceptance by the society.

Eligibility criteria:
Applicants need to fully comply with three eligibility criteria

1. Early-stage researchers (ESR) are those who, at the time of recruitment by the host, are in the first four years (full-time equivalent) of their research careers. This is measured from the date when they obtained the degree which formally entitles them to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the research training is provided, irrespective of whether or not a doctorate was envisaged. Please note that applicants cannot already hold a PhD at the time of recruitment.

2. Conditions of international mobility of researchers: Researchers are required to undertake transnational mobility (i.e. move from one country to another) when taking up the appointment. Researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of their host organisation for more than 12 months in the 3 years immediately prior to their recruitment. Short stays, such as holidays, are not taken into account.

3. English language: Network ESRs must demonstrate that their ability to understand and express themselves in both written and spoken English is sufficiently high for them to derive the full benefit from the network training

How to apply:
The job application in English consisting of a covering letter and structured CV should be sent to Mr. Libor Danek (libor.danek@img.cas.cz) by 30 November 2017. If you have any questions related to the positions, please send them to this email as well.

We thank all who apply for their interest; however, only those candidates who are considered for an interview will be contacted.

Additional information:
The Marie Skłodowska-Curie Actions offer attractive salary and working conditions The successful candidates will receive a salary in accordance with the national legislation of the recruiting institution and the Marie Skłodowska-Curie Actions regulations for early stage researchers. Exact salary will be confirmed upon appointment.

In addition to their individual scientific projects, all ESR will benefit from further continuing education, which includes scientific skills courses, transferable skills courses, as well as active participation in workshops and conferences and secondments to partner labs.

Each ESR will be hired for 3 years, full time.

The European IMGENE training network wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation.

IMGENE, This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 765269

Download the announcement of the job vacancy as a PDF file

Open Position

Grant Manager for CCP Research Infrastructure

We are looking for a grant manager to oversee financial aspects of our research and infrastructure projects. You will be responsible for finance-related grant administration including reporting, budget calculations, communication with grant providers and for cooperation with economic department of IMG. In addition you will assist with price calculation and invoicing for CCP research services.

You should possess a degree (preferably) in finance, economics, business, management or in natural sciences and/or have regular experience with grant administration of projects funded from ESIF/ERDF operational programs provided by MEYS, H2020, Czech Science Foundation or other providers.

Due to a nature of the position fluency in Czech or Slovak is a must and working knowledge of English (B1/B2 level) is needed.

Open Position

Senior Laboratory Technican / Transgenic Core Specialist (Embryonic Stem Cells / Transgenesis)

The Transgenic and Archiving Module of the CCP (http://www.phenogenomics.cz/) is seeking a motivated senior technician to join our international team.

Your key responsibilities will be work dedicated to embryonic stem cell (ESC) laboratory. This includes ESCs culture, back-up freezing, and their use and optimization for genome targeting by classical techniques and programmable nucleases (CRISPR/Cas) and validation of generated ESC clones. Partly you will support the team in rodent handling and operation (embryo transfer into foster mothers). In addition, assistance in general lab management, administrative tasks, and reviewing/supervising the daily subgroup work program will also belong to your tasks.

You should possess a master’s degree in biology, molecular biology, biotechnology, or related subject and must have experience in mouse ESCs culture, general laboratory work, and organization. Experience in rodent handling as well as knowledge in rodent genetics and transgenic technologies would be advantageous. Candidates must be fluent in English, have good interpersonal communication skills, and be able to work independently as well as part of a team. If you are an organized and responsible person, have a keen perception and like to establish new techniques in the field of rodent transgenesis, you are welcome to apply for this job.

Open Position

Pathologist (rodent pathology)

To advance and further improve services of our histopathology lab we are seeking experienced pathologist who will be responsible for analyses and descriptions of mouse and rat tissue samples, especially:
– to provide expertise in the pathology of genetically-engineered mouse (GEM) and rat models
– to provide full pathology analysis including complete gross- and histopathological evaluation supplied with image-based report, digital images, and recommendations
– to perform phenotype investigation and characterization together with histology-lab managing scientist; this includes necropsy, macroimaging, tissue sample collection, supervision of histological processing, histopathological evaluation, digital photomicrographs, and consultations.
– to follow and implement GLP rules and manage work of lab technicians
– to drive his/her own research projects and actively participate within the other projects of the Centre.

Successful applicant should have DVM or MD (or equivalent advanced degree in relevant field) and relevant research and/or hands-on experience. Capability to work in English speaking environment is a must, previous experience with SOPs for GLP is an asset.

Open Position

Research position (postdoc) in ubiquitin ligases or molecular biology

A postdoctoral research scientist position is available immediately in the Laboratory of Transgenic Models of Diseases  the Institute of Molecular Genetics of the ASCR, v.v.i. located in BIOCEV (CCP building) We undertake various approaches to understand the function of several E3 ubiquitin ligases by using mouse models with their potential to be instrumental for the study of the disease mechanisms, particularly cancer and inflammatory diseases.

We are looking for a highly motivated individual with a strong background and skillset in biochemistry and molecular biology. You should have a PhD in biology or biochemistry and have a good proficiency in English. Experience in protein biochemistry is a plus. Your work will focus on wet bench projects including in vitro, in vivo, and mouse models with the goal of elucidating the molecular mechanisms of ubiquitination mediated by RING-type E3 ubiquitin ligases.

Interested candidates should provide motivation letter, CV and contacts to at least two independent professionals who can provide reference.

Jobs in Animal Facility / Zaměstnání ve zvěřinci ÚMG

For information regarding jobs in animal facility please contact Mrs Marketa Rynekrova at marketa.rynekrova@img.cas.cz or by phone at +420 241 063 182. For those positions application in Czech or Slovak or English language are accepted.

Pro informace o pracovních pozicích ve zvěřinci ÚMG prosím kontaktujte paní Markétu Rynekrovou na emailu marketa.rynekrova@img.cas.cz nebo telefonním čísle 241 063 182. Pro tyto pozice přijímáme žádosti o zaměstnání v českém, slovenském nebo anglickém jazyce.

Open Position

Technicians for animal facility / Technik nebo technička pro zvěřinec

Hlavní náplň práce:
– obsluha a údržba laboratorních technologií zvěřince (zejména systémy chovných nádob)
– obsluha mycích a dezinfekčních automatů spojená s jejich údržbou

Profil vhodného uchazeče:
– ukončené středoškolské vzdělání technického oboru
– osvědčení dle § 6 vyhlášky č. 50/1978 Sb. o odborné způsobilosti v elektrotechnice
– znalost anglického jazyka minimálně na úrovni porozumění technického textu, komunikační úroveň výhodou
– technická zručnost a orientace v technické dokumentaci (včetně anglicky psané)

Pracovní podmínky:
– pracoviště – Ústav molekulární genetiky AV ČR, Praha 4, nebo centrum BIOCEV ve Vestci u Prahy
– atraktivní práce na předním výzkumném pracovišti
– příplatek na stravování
– platové podmínky odpovídající dané pozici
– nástup dle dohody

Open Position

Animal caretakers / Ošetřovatele laboratorních zvířat

Hlavní náplň práce:
– zodpovědnost za péči o laboratorní zvířata
– sledování zdravotního stavu zvířat
– samostatné provádění odborných úkonů
– efektivní podpora vědeckým skupinám ústavu
– zadávání chovatelských dat do počítače

Profil vhodného uchazeče:
– absolvent střední veterinární školy nebo střední zemědělské školy nebo jiné vhodné vzdělání
– samostatnost
– přesnost, spolehlivost
– základní znalost práce s PC
– praxe v oboru výhodou, úspěšnému uchazeči bude poskytnuto doplňující školení

Pracovní podmínky:
– pracoviště – Ústav molekulární genetiky AV ČR, Praha 4, nebo centrum BIOCEV ve Vestci u Prahy
– atraktivní práce na předním výzkumném pracovišti
– příplatek na stravování
– platové podmínky odpovídající dané pozici
– nástup dle dohody