We are enhancing our
understanding
of the genetic basis for
human diseases

What can we help you with

Microinjection

Model Generation

Genetically modified rodent models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. 
Phenotyping

Phenotyping

The genomes of humans, mice and other species have been completely sequenced, yet the knowledge of genome sequences as such does not shed light on questions concerning the functions of these sequences. 

Animal Facility

The Animal Facility Module of the Czech Center for Phenogenomics is based on the latest advances in housing, breeding and care of laboratory mice and rats. 
Mouse tumors

Preclinical Testing

The Czech Centre for Phenogenomics can offer a very broad portfolio of highly standardized assays useful for preclinical studies on rodents including established disease models. 

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Latest News

25. 03. 2024

Upgrade of the large research infrastructure CCP III

The goal of the project (ID: CZ.02.01.01/00/23_015/0008189) is to modernize the large research infrastructure of the Czech Center for Phenogenomics with the aim of maintaining its competitiveness and expanding the portfolio of services. The project comprises of three key activities (KA): KA1 – Project management KA2 – Modernization and upgrade of large research infrastructure KA3…

21. 03. 2024

CCP succeeded in the EIC Transition call

Czech Centre for Phenogenomics (Institute of Molecular Genetics of the Czech Academy of Sciences), which is a partner in the project TREM2MEDS – Towards the clinical implementation of TREM2 microglia engineering for treating dementia, succeeded as the only applicant from the Czech Republic in the EIC Transitions call. TREM2MEDS (coordinator: Universita degli Studi di Padova, Italy)…

27. 02. 2024

Apply for CCP services: Generation of precision cancer mouse models using CRISPR-Cas9 and In-depth cancer-based phenotyping of cancer mouse models

Open Call for Transnational Service Provision under the canSERV Open Call The researchers are welcome to apply to a portfolio of services offered by canSERV to address the research needs of the entire oncology developmental pipeline. CCP offers following services in this call: For more information visit canSERV website. Submission Deadline: 21 May 2024, 2pm…

About Czech Centre for Phenogenomics

Genetically modified mouse models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. Crucial for this technology is the ability to control the expression of genes of interest. It is possible to increase or decrease gene expression, or eliminate the expression of a gene completely.

Transgenic and gene knockout/knockin technologies have become important experimental tools for assigning functions to genes at the level of whole complexity of organism, creating models of genetic disorders, evaluating effects drugs and toxins, thus helping to answer fundamental issues in basic and applied research.