Czech Centre for Phenogenomics
2 2023

Dear Colleagues,

Three months of the year 2023 have passed fast and we bring you news from CCP life again.
Please also check our website and follow our Twitter account @CZphenogenomics.
Enjoy the reading!
Radislav Sedlacek and the CCP team

The new state-of-the-art BSL-3 laboratory at the Czech Centre for Phenogenomics

The new state-of-the-art BSL-3 laboratory for work with highly infectious viruses and bacteria was opened on 9 March at the Czech Centre for Phenogenomics. The new laboratory will be used primarily for preclinical testing of new drugs in animal models.
Press release

CCP preclinical services in a nutshell

The Czech Centre for Phenogenomics offers a very broad portfolio of highly standardized assays useful for preclinical studies on rodents including established disease models. Are you interested in our preclinical services?
Download our latest overview of services we provide to our users in the area of preclinical services.

Focus on rare diseases: the Alliance for Rare Disease Research and Therapy is launched

The Alliance brings together leading Czech scientific and medical institutions dealing with rare genetic diseases as well as patient associations. It also plans to work closely with specialized companies.
Since 2022, CCP coordinates the research programme “Towards Precision Medicine and Gene Therapy” of the Strategy AV21 of the Czech Academy of Sciences. The other project coordinated by CCP is the “National centre for new methods of diagnosis, monitoring, treatment and prevention of genetic diseases”. The project started in January and is aimed at supporting and strengthening long-term cooperation between the research and the application spheres. Rare diseases, which are studied at CCP, cover: Angelman syndrome, Netherton syndrome, Prader-Willi syndrome, Diamond-Blackfan anemia, osteogenesis imperfekta, achondrodysplasia.
On the occasion of the world Rare Disease Day experts from CCP participated in two events in February:
International day of the Angelman syndrome
Recording in Czech is available on YouTube.
Focus on rare diseases: Panel discussion Recording in Czech is available on YouTube

Open access to CCP services under transnational calls

Generation of new study models for SARS-COV-2 research. More information:
Disease Models – Generation of precision cancer mouse models using CRISPR-Cas9 + In-depth cancer-based phenotyping of cancer mouse models.
Morei nformation:

New publications

Scientists from the Czech Centre for Phenogenomics participated in the characterisation of the effect of the antibodies by creating special mice that model Covid-19 infection in the lungs.
Full text:
CCP publications


Blanka Mrazkova, young postdoc from CCP was awarded the best talk at the Neural Crest & Cranial Placodes Gordon Research Seminars 2023 in Renaissance Tuscany Il Ciocco in Lucca, Italy. Blanka presented her research about the role of Trabd2b gene in mouse head and brain embryonic development. Her results suggest that this gene sustains the balance between Wnt and Shh signaling pathways.
PhD student Miles Raishbrook from the Czech Centre for Phenogenomics was awarded with the January Picture of the Month. Competition is organized by the Imaging Methods Core Facility at BIOCEV campus.
Visualising the site of phototransduction. TEM image of a mouse’s rod photoreceptor outer segments (pseudocoloured to delight your cones).

Job offers

For currently open positions please visit our website.
Czech Centre for Phenogenomics
Institute of Molecular Genetics of the
Czech Academy of Sciences