General information

With staff over 100 people the CCP is one of the largest national research infrastructures in the field of biomedicine. The center is located in the municipality of Vestec south of the capital city of Prague in the Czech Republic. Set on the campus of the BIOCEV, CCP is a state of the art facility combining the generation, phenotyping and archiving of rodent strains. As a member of the International Mouse Phenotyping Consortium (IMPC) and INFRAFRONTIER, CCP is dedicated to the goal of systematic genome-wide phenotyping project of knock-out mice in order to provide the broader research community with a lasting resource of mammalian gene function

The CCP is part of Institute of Molecular Genetics of the Czech Academy of Sciences (IMG), leading Czech research institute in the field of molecular biology and genetics.

The applications in English including letter of interest & structured CV and (if relevant) list of publications and letters of reference should be sent to Mr. Libor Daněk via email libor.danek@img.cas.cz.

What we offer to our employees?

A stimulating and challenging work environment, opportunities for career advancement, competitive salary and wide spectrum of benefits. The positions are available immediately (if not stated otherwise) for an initial fixed-term contract (1 year) with expected longer-term extension upon demonstrated proficiency.

We thank all who apply for their interest; however, only those candidates who are considered for an interview will be contacted. All vacancies are open until filled or otherwise stated.

All positions have place of work in BIOCEV campus in Vestec in close vicinity to Prague.

Currently we are seeking candidates to following positions:

Research Specialist for Immunology Unit

As a research specialist in immunology unit you will be responsible for

– Running and developing phenotyping procedures for systematic characterization of novel mouse/rat models
* Primary standardization of procedures according to International Mouse Phenotyping Consortium
* Development of advanced immune-phenotyping assays
* Development of secondary tests for revealing immune system dysfunction under challenged conditions
* Development of automated analysis of flow cytometry data
– Conducting individual research projects to increase the knowledge base of CCP
– Serve and cooperate with CCP users
– Managing workflow of the unit and its staff
– Active contribution to team work in complex multi-disciplinary projects covering multiple aspects of physiology.

Best candidates should:
– possess a PhD in immunology, biology, medicine or related subject and have relevant track record in the field (not mandatory)
– possess excellent skills in flow cytometry
– have experience in rodent handling as well as knowledge in rodent genetics
– be fluent in English (written and spoken)
– Experience with PDX models would be considered advantageous.

Unit Head for Lung Function Phenotyping
The lung function unit is part of standardised phenotyping pipeline, which is involved in IMPC phenotyping effort. The lung function unit focuses on understanding the role of both genetic, environmental and pharmacological factors on lung physiology, homeostasis and mechanics in mouse and rat models. Unit is in close collaboration with other units dedicated for cardiovascular, immunology and histology research and its work is supported by all units within phenotyping module i.e. cardiology, histopathology, bioimaging, electrophysiology, metabolism, PDX and Cancer models etc.

The main responsibilities include but are not limited to:
– Organisation and supervision of the unit including management of lab technicians or specialists
– Design and running of experiments including direct ventilation with Scireq devices with standard and advance measurements of lung mechanics parameters, tissue collection and immunological analysis of lung disease models.
– Data analysis and interpretation
– Oversee the optimization of current procedures and development and establishment of new techniques, secondary tests and challenges
– Writing and maintaining SOPs
– Supervision and consulting of complex projects related to lung and cardiovascular system
– Involvement in writing grant applications and in publications
– (Future) possibility to run own research projects

The successful candidate will hold a PhD in a biological discipline with proved experience in lung physiology. Must have experience with handling and working with rodents especially mice and rats. General laboratory experience and knowledge of substance administration is important but not essential. Previous experience with Scireq devices and ultrasound imaging (Vevo system) is considered advantageous as well as experience with pharmacological treatment of lung disease models.