CCP generates rodent models related to diagnosis, treatment and prevention of COVID-19 virus infection (e.g. several serine protease mouse mutant lines). Project proposals can be submitted by email to ccp@phenogenomics.cz

Proposals will be evaluated and conducted with the highest priority.

Available resources, service & support:

  1. Generation of rodent disease models (knockout, humanized, etc.), relevant for COVID-19 research. In particular, the CCP can offer several serine protease mouse mutant lines (Prss35, Prss12, Prss21, Prss33, Prss55, Prss37, Prss47, Prss54, Prss48, Prss44, Prss57, Klk12, Klk15, Klk11, Klk13, Klk10, Klk8, Klk5).
  2. Standard cryopreservation and archiving services (sperms and embryos) are maintained.
  3. Advanced secondary phenotyping  pipelines relevant to lung inflammation and fibrosis (including state-of-the-art imaging, immunology, lung function).
  4. Pre-clinical testing (lung inflammation and fibrosis models – clinical biochemistry and histopathology are conducted under GLP conditions).
  5. Metabolomics and MALDI imaging from tissue samples and biopsies depending on capacities.

Prioritization call in place to support projects investigating the SARS-CoV-2 infection and its treatment.

Contacts:
General service contact: ccp@phenogenomics.cz

Specialized service contacts:
ccp-tam@img.cas.cz (model generation, archiving & distribution)
ccp-pm@img.cas.cz (phenotyping & preclinical service)