The Czech Centre for Phenogenomics will be unique in combining genetic engineering capabilities, advanced phenotyping and imaging modalities, specific pathogen free (SPF) animal housing and husbandry, as well as cryopreservation and archiving, all in one central location – at BioCEV (link). This concentration of specialized infrastructure and expertise will provide a unique and valuable resource for the medical research community.
The Czech Centre for Phenogenomics (CCP), through its membership in INFRAFRONTIER, is a partner in a collective global network that aims to comprehensively and systematically analyze the effect of loss of function gene mutations in mice. The goal is to produce a comprehensive ‘encyclopedia‘ of gene function, that will help identify causative factors of human diseases as well as novel targets for therapeutic intervention. Through the adoption of standardized procedures and pipelines, and the usage of quality control measures and cross-validation, our shared goal is to produce high-quality data that will not only function as a scientific reference catalog, but will also enable comprehensive meta-analyses that could uncover otherwise hidden disease relationships and functional interactions. By focusing expertise and resources and coordinating our efforts to avoid redundant work, we will help achieve these goals in a more cost-effective manner.
The CCP has planned for its phenotyping capabilities to accommodate both mouse and rat disease models. Although the mouse remains the most cost-effective choice for comprehensive phenotyping, the rat remains a better model for a number of human conditions, including cardiovascular disease, diabetes and behavioral disorders. Through the generation and focused phenotyping of prospective rat models, where gene targets have been identified through the systematic mouse phenotyping effort, we can focus our complementary analyses to conditions where the larger size and higher cognitive function of the rat is advantageous for more complex and accurate physiological assessments.